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                  <text>-

,.

.«w—v'7' —u w'—"uw

A

n.

7*“ may

June 15. 1972

John m. Davis, M.D.
Department of Psychiatry

Vanderbilt University
School of {wiediclne

Rashville, Tennessee

37232

Dear John:

I have read your letter, "Chotinekgic Revenbaz 06 Manic
Symptomo" in the Lancet of June 3 with much interest. The role
of cholinorgic mechanisms in depressive states ané their treatment
has been ignored for too long, and such data as you present is most
role of cholinergic mechhelpful. Some years ago, we reviewed the
we were intrigued by
ECT.
of
by
depression
anions in the relief
diethazinc,
benactyzine,
of
cnticholinorgics
(g;g.,
the ability
such
physiological
ECT
(and
induced
improvement
Ditran) to reverse
I am
EEG)
states.
and
depressive
the
to
exaggerate
indicer as
thooc
otudiea,
summarizing
of
a
reprint
enclosing
the
taking
liberty
own.
complcmentary
to your
as
But I am writing because I am particularly interested in
your comment, "... that norihuann*induccd euphoria and talkativencss can be converted to a severe depressive syndrome by phyoostig~
mine". I do not recall these data at the APPA meeting. and I am
to
writing to ask if a copy of that report can be made availablewith
interactions
by
of
effects
of
The
method
drug
analysis
us.
known pharmacologic agents is one that we have just begun to apply
to our studies of cannabis.
ﬂany thankn.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

ﬁfzig
Enc.

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