http://exhibits.library.stonybrook.edu/mfp/files/original/e7fe7e9ca75c6e48fc2315886367dd36.pdf 30327f93c1690aea8f96ff938d3f2e3d PDF Text Text EEEQEAEQEE June 22, 1972 To: A. M. Freedman, M.D. FROM: Max SUBJEC": Proposal, ”Effects in Man of the Chronic Administration of Hethadone or Cyclazocine“ Fink, M. u . proposal is an experimental study in addicts, involving tongue biopsis and infusions of methacholine and Zenorephrinephrine to define cholinergic effects of methadone (or cyclazocine). The study bears no direct or indirect benefit to the subjects. The proposal alludes to some experimentation data on the mouse and salamander, but it is not clear wnat the relevance of these data The for man may be. author treats methadone and cyclazocine as if they were equivalent drugs. For example, what print data was obtained in animals with cyclazocine? The The protocol is incomplete. How many subjects, how selected; and by whom? What will be paid the addict volunteers? If not paid, what benefit will they get? If any is part of treatment regimen, who is responsible? What will be done with the samples? infusions are cited but for the protocol, we do not know how subjects will be selected; who will be present, what duration and what criteria for the end of infusion. What of the blood pres— sure effects? How will vagal effects be assessed and how will subjects be protected? The In sum, the protocol is incomplete, particularly as i ’ to the selection of subjects and benefits for subjects ting. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Freedman, A. M. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-026-2-155 Date A point or period of time associated with an event in the lifecycle of the resource 1972 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence