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                  <text>-.

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January 24, 1972
G.

F. Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Cary,

The Lord

preserve us from.the enthusiasms of childred

!

Your letter about the M5050 situation was most welcome, but
the situation is murky, confused, disorganized, and typically American—during the War, we described the situation as SNAFU.
To recapituiite: our laboratory became interested
in the antagonists in 1967. We heard of diprenorphine and contacted you,
as well as Lederle. They were uninterested~~ you and we were. We proposed
a study of the animal toxicology, peior to obtaining an IND to assess its
activity in man. We requested funds of the New York State Commission,
but were denied. We tried NIbiB, the Cityoof New York, and private donors-~

and each

felt that

such

trials

were the expense of

industry.

tried Nlhi,

and they were receptive, and.
Meanwhile, the White House
appointed a brash, young man to h.ead its program; and he asked for assistance
from other brash young men, without experience. Nevertheless, when they
called me some weeks ago, I shared the full file with them, for
is
irrelevant to me who provides the support for the animal work. They
called to ask how much material I had, how much would be nodded, etc. I
answered, openly, and offered the material in hand to start, and indicated
that I would write you for additional material as needed.

Last

summer, we

hence the application which you read.

it

last week, Dr. Green told me that he had assumed full
the program; that he had called you; that there were
for
responsibility
the usual bureaucratic complications of the precedence of a U.S. grant to
do the work of industry, and who would get the rights if the material was
successful, etc. I suggested he review the massive contracts between the
military and industry, and that he disregard the trivial amounts necessary
heae. But, he indicated, that I did not understand his many problems, etc.
Then,

MIME has indicated that they will fund the grant
of
first April; and the City of New York has indicated that they
fund
animal trials, if I guarantee that we would have enough
the
will
do
the clinical work thereafter (which I did); and Drs. Green,
material to

about the

Meanwhile,

Jaffe, et al. are

runnung about.

.

.

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My reaction is similar to what it was last summer—- to take
holidays. I am off to Greece for the week, and hopefully, the various
competing agencies will resolve their problems.

some

Our position is what it was two years ago-- we are prepared
interested in establishing the clinical efficacy, dosage range,
toxicity, utility, and anything else that may be interesting of the antagonists
in opiate dependent subjects. We are now embarked on essays of naloxone

and

pamoate; have been promised l-cyclazocine next month; and

BC

2605

in

Should some agency probide the basis for an IND, we will do
what we can-- and hopefully, R 8 C will make some material available
for our studies at that time. Or, should I husband my present supply,
and let MIME, Green and Jaffe, and New York City obtain their supplies
from you ?

April.

Incidentally, in the usual disorganization of our governement,
will probably get out funds, eben if the toxicity is done at the
military centers in the v.3.

we

I look forward to meeting John Lewis again. There may be

error, however, for I believe the Drug Dependence meetings are
to be held in the late Spring in Ann erbor and not in February-— unless

some

he

is

coming to a committee meeting and

scientists in the field.

that is not

open to the

Keep weal, and do what you must to secure your compound's
study. While I would like to be its monitor, I do not see how I can ask
us are brash, and unSOphisticated, and tend
it, for the forces aboutwherever
and whenever they can.
to assert their powers

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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