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                  <text>January 24, 1972
Walter Essman, Ph.
Queens College

Flushing,

D.

New York

Dear Walt,

I would be pleased

if

you would consider an evaluation of

the central effects of 01—63, the l~10 polypeptides of ACTH, with a view
to elaborating the observations of DeWied and of Indrocki. We have
assessed the EEG effects in volunteer males, and in our pilot study have
observed systematic changes to 10-12.5 mg intravenous. The changes are
seen withing a half an hour. The effects are more prominent and somewhat
unpleasant in dosages of 15 and 20 mg. These data are insecure, however,
and require verification in a systematic study, which I plan to undertake

this spring.

Should you wish to study this compound, the monitors at
Organon are willing to allow some of the material to leave my laboratory;
and should there be some eXpenses for the chemistry, I amy be able to
obtain some support. I am most interested in your opinion as to whether

the

data justifies the conclusion that the drug may have effects
and thus may justify studies in man during the ECT process.
I had suggested such a study to Dick Abrams, and it was he who reminded me
that your methods are probably much more sophisticated than our human

on

DeWied

extinction,

methods

for such evaluations.
In addition, I

am

I will call

my

enclosing copies of the reports sent
his ddta in your
presentation at the meetings in April.
by Dr. Dunn. I would hope

that

on

you would include

return later this

me

month.

Sincerely yours,
Max

Fink, M.D.

""u

"”1“

A’WUW“

P.S.

Can you

vet

my

application to the Neuroscience Society

7

Thanks.

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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