http://exhibits.library.stonybrook.edu/mfp/files/original/f28e33fa1acf043e0bb55807ef9f35f3.pdf 27d7263df3b0304fa63619217fa58686 PDF Text Text February 5, 1972 Paul Janssen, M.D. Janssen Pharmaceutics Beerse, Belgium Dear Paul, I have first You gave me so much sorted my thoughts to think about during this week-end. my visit, that I am most delighted that such longer acting narcotic antagonas R 15497 provide a basis for further development. Should the minimal toxicology data, and supplies be available, we will file a research IND with the FDA, and undertake the clinical testing to assay the dUration and extent of narcotic antagonism (measured as the response to intravenous heroin, 25 mg/2 cc saline/2 minutes) in post-withdrawn opiate dependent subjects. We would also evaluate any agonistic features. ists Should it prove to be an active antagonist with a duration greater than the available the long-term clinical compounds, we trials. will support and undertake I called Dr. Allan Green (U.S. Special Action Odfice, The White House) and Dr. Jean Paul Smith (National Institute of Mental health) Center for Studies of Drug Abuse) to tell them that I had reviewed some of your compounds of interest; that these had been tested by the University of Michigan and the data were in the appropriate archives; showing these compounds to be similar to others already under investigation; and that prior to further study, they required, as with M—SOSO, additional formulations of supplies and animal toxicology studies to satisfy the FDA. Dr. Robert Rees also called and I repeated these observations. variety and special characteristics of your many new fascinating. 0n the return flight, I read the many clinical reports carefully, and am impressed that penfluridol should be an The compounds were important improvement over our experiences with fluphenazine enanthate and decanoate. I would like to evaluate penfluridol in our V.A. unit. I have given the data to my associate, Dr. Alexander Don, and we will write to Dr. Stevens at MsNeil, to ask him to visit with us on his next trip to New York. �. L“ man‘s “ac-'9. Paul Janssenll.OOOIOOOIOOIIOOOOIOI. 2 IClo...-OIOOIIOOIIIIOFebruary 5, 1972 The usefulness of tetramisole as an antihelminthic is dramatic, and the possibilities in oncology most exciting. It is the alleged antidepressant activity, however, that interests me. We are assaying one compound, ORE 8063, from Ortho Research, in our EEG screen, but our methods may be more appropriate to examine the possible central activity of tetramisole. I will call Dr. Bill Pollack as you suggested. With regard to haloperidol in addiction, I have reviewed the available to me, and the suggestion by Lal is interesting, though poorly substantiated.. I have intererted an experienced member summaries of my staff, Richard Resnick, to examine the data and he will design a study, which will run in parallel with the ongoing trials of narcotic antagonists. I enjoyed discussing and reading the descriptions of the compounds other in your catalog. You are to be congratulated many and the Special characterittics of your products. A on variety 30-day narcotic antagonist would complement your list most dramatic- ally! visit visit Your hospitality was exemplary; your family charming; and the most memorable. Please give Dora my best, and trust that your 'down under' will be exciting and interesting. My thanks for your many, many kindnesses. Sincerely yours, “Whittx’GVG—"m' ,_ rw m"‘-v. waw-vwmcm-mmwui-Wmam 7r—’ wai' Max Fink, M.D. Professor of Psychiatry � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. 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