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                  <text>February 8, 1972

Prof.

Hebrew

Israel

R. Mechoulam

University of Jerusalem

Dear Prof. Mechoulam,

&lt;7

:-

Mammy-”WV

I have just returned from examining some of the chronic
hashish users in the laboratory of Prof. Miras in Athens. We observed
4 men as they smoked various doses of hashish, U.S. grown marijuana,
THC impregnated placebo marijuana, and placebo marijuana. Our data
is confusing, for the men exhibited 'tolerance' to hashish, but not
to marijuana; they showed behavioral changes to marijuana which seemed
distinguishable from their responses to hashish; and they showed
no reaponse to 75 mg THC.
One

&lt;v:

is the different

of the

mix of

possibilities underlying these
constituents in the

mixed observations

two samples. Before

leaving

Athens, Prof. Miras provided us with another sample of hashish which
has a low concentration of THC, and the men reported this sample to be

'without

effect'.

are replicating these observations in another sample;
THC~A~9 and ~8. I have some
samples of the two types of hashish, and the U.S. marijuana, and I am
writing to ask if you would be willing to assay these for us. There
is some question in our minds as to the actual concentration of the
presumed active substances. May I send 4-6 samples to you ?
and

We

will undertake additional trials with

Many

thanks.

O

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
“swap-7m

vvm-J

rummrvrr‘r'

~
"“7

=

-.

W‘V'm'li‘

mam.

“Mvm‘cvir

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              <text>1972 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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