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                  <text>-., ‘4’

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March 27, 1972

Donald Gallant, M.D.
Professor of Psychiatry &amp; Neurology
Tulane University School of Medicine
New Orlean, La. 70112
Dear Don,

I read your impressive ECDEU report with interest-~
particularly the data on GR? 8063 and the neurophysiologic studies.
But one issue stood out, that of the EKG effects of thioridazine.
You report extensive and persistent EKG effects of thioridazine and
meaoridezine. In our studies in St. Louis, Turan and I were also
impressed with the EKG effects of thioridazine, in ﬁber studies of
chlordiezepoxide and thioridazine.
This data becomee even more important when we review the
data
clinical
for thioridazinc, for this compound is no better than
other ontipeychotic drugs, and occasionally has been rated as worse.
Why,

limited to the

then, is the drug not withdrawn; or, as with iproniazid,

few cases of confirmed therapeutic failure with other agents
ECDEU
Perhaps the
group could discuss this question in Spring Grove
in June, and if other investigators agree, bring the data to the attention

of the

FDA.

Or, do you

changes are so trivial as
functions in these patients!

feel that the

not to affect the cardiovascular

EKG

I look forward to seeing you in June.
Sincerely yours,
Max

cc: gerome Levine, M.D.
PRE-NIMH

Fink, M.D.

?

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