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                  <text>December 9, 1971
Dr. Robert Rees
SAODAP

The White House

Washington, D.C.

Dear Bob,

are pleased to enclose a protocol for the study
of narcotic antagonism
of l~cyclazocine~- to assess the degree
in post—addicts, and the relation of an effective 'therapeutic'
while we will be preoccupied with
dose to secondary effects.
we believe
our studies of naloanone pawste during the next few weeks,
the middle
about
beginning
we can evaluate this compound concurrently,
of January.
This protocol will be submitted to the appropriate
committees of the College for their concurrence, but we anticipate
We

no

difficulty.

Should the supplies be available,

is a choice) to

have

we

would

l-cyclasocine presented in the

scene

(if

there
concentration

prefer

and the scene vehicle as racemic cyclasocine. If manufacture is no
problem, we would request an initial supply of 1200 mg» sufficient to
assess the effects in 8 patients for 4-6 weeks.
Many

thanks

for your cooperation.
Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

mf/
V

:rar

:

.

�</text>
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