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                  <text>December 17, 1971

Professor Ian Oswald

Department Psychiatrist

University of Edinburgh
Royal Edinburgh Hospital
Edinburgh Ed lU~5
Great britain

HF

Dear Ian:

It was good to hear your report in Mexico City, and on my
nad
the occasion to re~read your report on fenfluramine
I
return,
and imipramine. As I understand your thesis, the abuse potential
is “blocked” by initial unpleasantness, or unpleasantness during
withdrlwal. This suggestion is descriptive enough, and is probably
accurate. Some years ago, we attempted a sudden withdrawal from
imipramine and found our subject to develop “withdrawal“ symptoms
(Withdrawal Symptoms Following Discontinuation of Imipramine Therapy, American

J. Psychiat.,

118:

549~550, 1961).

it

not true that ”dependence” develops to all drugs, given chronically? We have observed, and others
reported, withdrawal effects for phenotniazines and antihistamines,
and I would expect careful studies to show withdrawal to other drugs.
Using your model,

My

is

YOur suggestions are provocative, as was your presentation.
best wishes for a successful and nealthy 1972.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Ming

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