http://exhibits.library.stonybrook.edu/mfp/files/original/28c9d0c13ee36a13bdf529237caf5e4b.pdf 462a2d9072d3ea3282a86e6decb3f591 PDF Text Text .7...__ cavvr , . w“..-r_._._._- ”us—1.. wwwww—v... Mr 3..“ -m ”aura-w. . . .mwr-twwwm~mw .m. my”, W-..i....r. Hovssbsr 18, 1971 Robert Rees. H.D. Special Action Office For Drug Abuse Prevention White House Hashington, D.C. 20506 Dear Bob: Since the September meeting of SAODAP, we have reviewed our programs in New York and Al Freedman and I are writing to acquaint you with our immediate projects. sured We plan to expand our studies of nsloxone. We have been as— by Ralph Jacobson that naloxone pamoate will be available for by the end of the year. We have filed the necessary clinical forms for an IND, and will give this study our highest priority. We trial are also continuing our studies of high dose oral naloxone, and are t testing dosages from 1.0 to 1.8 grams. This study will parallel the psmoste. In both studies, we will assess the duration of antagonisiu with heroin challenges and clinical acceptability. Our interest in M—SOSO and BC 2605 has led us to file and N.I.H.H. application for support of the antagonist studies. The applicstion requests funds for the necessary animal trials to obtain an 1RD for M-SOSO, and should we obtain this IND, we will assess the du~ rstion of sntsgonisu sad sccsptsbility as an antagonist in our clinical population. We have not made s psotocol for BC—2605 since our facilities sre cousitted to thsss prior studies. To expand our facilities, how— ever, so srs sstshlishing s clinicsl research unit at the Montroso V.A. One of my students. Alexsnder Don, hss sgrssd to set up the unit and hss joinsd thst staff this week. �Robert Rees, M.D. recently completed our comparison of l-slpha-acetylsethedol that report was sent to your office. We believe that this compound can be used more widely and further testing should be done. We have urged Dr. Richard Brotnen of our College to undertake a large scale clinical study, using the College methadone de~ toxificetion program as a base, and he is preparing the necessary doc— unentation for city authorities. We and methadone, and a copy of Bristol has requested that we assess the safety of naloxone: in a ratio of 1:10, and one member of our staff. Dr. Richard Resnick, has written a protocol for this study. methadone 0 ..'ervr-~ -:':' 'Ir' Wutv'r‘n wo‘rw. November 18, 1971 chiatay; Our latest cyclsxbcine report is in press in Comprehensive Rayand the report of our methadone—cyclesocine transfer study is being revised following editorial criticism. Our trails with silsstic/naloxone are not funded beyond the end of the month. The data are interesting, suggesting that is fea- it sible to delay the release of naloxone, but are not sufficiently conclusive to warrant our enthusiasm. heroin, Under another program, we are continuing our EEG studies of with one aim the development of an objective index of narcotic antagonism. We are also studying the neurohumorel consequences of opiate use; and our cannabis program is most active. But these issues are of less immediate public concern. Should your office obtain funding, two of these projects wer- Iant your attention: animal toxicology of M-SOSO sufficient for an IRD, as described in our N.I.M.H. protocol; and a large scale comparison of nethedol and methadone. While we have not prepared a protocol and bud~ get, this can be done. wish to implement the recommendation that addiand pro-clinical testing of analgesics and antagonists be establishdd, we have reviewed the facilities and personnel available in New York, and believe that a viable program could be es— Should SADDAP tional centers for clinical tablished, capitalizing facilities. on the affiliated college, city, state, and V.A. Finally. there is one delicate matter that should be brought to your attention. In discussions with Ralph Jacobson, he has repeat— edly alluded to the support from your office for the naloxone studies in this institution. We did discuss funding from Endo with his, in part, for the special tests and reports that they usually require at the end of each study. Also, in our discussions with Dr. Irwin Pechter of Bristol Laboratories, we have indicated that support of our study programs is essential to their vitality, and that transfer of this support to governmental agencies are not particularly useful. (You may recall that Ster- �November 18, 1971 Robert Recs, M.D. ling~w1nthrop provided us with funds for our cyclczocinc studios ~fundo that wcro used for oquipncnt. travel, and consulting not ordin— arily available in governmental contracts). I would hope that the parof ncrcotic allel, direct Iupport by Endo and Bristol, of then: studios antagonists, will not be projudiccd by implied proniocs from SAODAP. ‘- 'H'srxw-"mro'ivv-uuv v We trust those succcooful launching of comments SAODAP are uscful, and look forward to tho in tho near future. programs Sincerely yours, Mu Fink, , at, WIN“ V‘Rfl‘ "' '-r"smm- HOD. Professor of Psychiatry 42v" HF:ig � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Rees, Robert Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-8-500 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence