http://exhibits.library.stonybrook.edu/mfp/files/original/acc848d986b6d2be85db285869f8214c.pdf 895a40b41b29ffcc3c3a217bc64ea324 PDF Text Text Novcmbcr 22, 1971 fiarold Mciselas, H.D. Commissionor Narcotic Addition Control Commission 1855 Broadway York, flew York 10323 New Dear narold: I have road the list of Suggested examinations for methadone was suggested for research or as the basis for a more complete examination of methadone treatcd patients. As a caries of research issues, the suggastions are vague and seem to reflect a general clinical neurologists' approach to a problem, without appreciation of tho complexity of the interaction of opiate dependence, its complications, and methadone. effects. It is not clear whether this list (1) Clinical exam: routine medical, and usually unchanged by methadone. The "mental status”, of course, can be very detailed and euphorigunic, (2) (3) (4) is the basic for exhaustive studies of memory, perceptual, 355, effects of methadone. ouch a routine EEG is of very limited value. In the studies that have dissected the EEG effects of methadone, quantitative measurlncnts were necessary. These did not show significant regional differences and from our past cx~ variance, such differences are rare with drugs. EEG: few Ancillary interesting theoretic speculation, with Despite many studies of drugs, the changes only ct very high dosages, and tho-o hcvc usually been non-contributing to our understanding. EEG: little foundation. AER shows 20M: interesting, but probably of little relevance to nothadonc‘s mode of action. Again, only changes at very high doccc of drugs or with those which specifically affect labyrinth: or vcstibulor nuclei (0.3., barbiturates, esthctica). an~ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Meiselas, Harold Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-8-495 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence