http://exhibits.library.stonybrook.edu/mfp/files/original/e6b3620451c8fca1c724ba0a04ddf83d.pdf 556046613f382308edcd64a0c847c5dd PDF Text Text \J I" flovembcr 22, 1971 Harold Moisolao, 8.0. Commissioner Narcotic Addition Control Commission 1855 Broadway New York, New York 10023 Dear Harold: I have read the list of suggested examinations for methadone was suggested for research or as the basis for a more complete examination of methadone treated patients. As a series of research issues, the suggestions are vague and seem to reflect a general clinical neurologists' approach to a problem, without appreciation of the complexity of tne interaction of opiate dependence, its complications, and methadone. effects. It is not clear whether this list (1) Clinical exam: by methadone. routine medical, Tue "mental very detailed and euphorigenic, and usually unchanged status”, of course, can be is the basis for exhaustive studies of memory, perceptual. Egg, effects of methadone. (2) such a routine EEG is of very limited value. In the studies that have dissected the EEG effects of methadone, quantitative measurement: were necessary. These did not show significant refusal differences and from our past exporionceg such differences are rare witn drugs. (3) Ancillary EEG: interesting theoretic speculation, with little foundation. Despite many studies of drugs, the AER shows changes only at vary high dosages, and these have usually been non~contributing to our understanding. (4) EEG: few Bode: interlacing, but probably of little relevance to nothcdone's mode of action. Again, only chnngcs at very high doses of drugs or with that: which opecificolly affect labyrinth: or vestibular nuclll (2.3.. barbiturates, actuation). an— �Harold Mbisolnn, M.D. Novonhot 22, 1971 similar to 3, 4. (5) Blood flow: (6) significant test, which is under study in many laboratottes. Thar: at: at least 3 important issuau: Rt undo: oinulntod conditions (9.3., drowsy); simple R.T. and complex R.T. Also, intranodnlity and internodslity issuas are critical. If done preperly, such a program could be of interest (oopecially simulated R.T.). (7) Conduction volocity: as prepared, a test of limited value. This in a highly complex procedure that may (like R.T.) warrant intensive study by exports, using sophis~ Rt: A ticated methods. For each item, 1~7, there is methadone treated aubject. in each I fly trust those comments little merit as a ”routine" test are responsive. If not, please call. best. Sincerely yours, Max Fink, H.D. Professor of Psychiatry MF:ig � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Meiselas, Harold Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-8-493 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence