http://exhibits.library.stonybrook.edu/mfp/files/original/b51601c109c535b81bf6f8da331aaa9c.pdf 87961cb8fd34f7198e8177f67fb9669e PDF Text Text ._.W_,..r... _. .1wh... . . 'vayvi- .. .1. v...—w...,._...y-v—— - Hovaaber 23, 1971 Dr. R. Mechoulam Laboratory of Hatural Producta of Pharmacy The fichrew University of Jerusalem Faculty of Medicine Jerua elem , la rael The School Bear br. Mechoulam: Separately I have sent you the import permit of EA 1476. There is much interest in the antagonists, and particularly in a long acting formulation in this country. I have attended two meetings focused on this problem during the past month. The immediate focus of interest is in naloxona pamoate, which in animal trials releases naloxona for 10—14 days. we will begin an assay of this material in January. At present, the two best antagonists are naloxone and l—cyclarocinc,. Naloxone is enclosed. For l-cyclaaocinc, samples would have to be ob— tained from Dr. Sidney Archer, winthrop Laboratories. It is also probable that fi~5050 of Beckett & Coleman may to useful, but neither lccylaaocina or M—SOSO have racoivad touting in man. Therefore, for the present, nal~ ozone in the drug of choice. Should you believe the chemistry of cycleaocino would be a better choice, I would suggest you write Dr. Archer for a sample of l-cyclazocino to test. The testing is a problem. I recall that the Israeli pharmacologiata were able to assay the duration of action in animal subjects, uaing morphine challenges. Ia that correct? Our facilities permit us to aaaay the duration of antagonism in nan, using heroin challenges. Ha have not been able to undertake toxicology studies in our laboratories, and have been trying to obtain the funda to study M~5050 under a contract. Thio it under review. Should you uaka some aanplaa available that you believe has a long release rate, we will try to assess the animal duration (rclcaae) and if intaraating, arrange for the other trials. �w rrv ‘mII—u -m,.—,_..vwn—.J,u‘“ .“pwwfifl.” .wu.n...,wm,wwwrvywvwfiw, November 23, 1971 Dr. R. Mechoulam chare grateful for E ' be remembered to you. your interest, and Dr. Freedman asks to Sinceraly yours, ..W-wvv'fl Max Fink , 14.1). Professor of Psychiatry :ig lie. biF mw—mmrmw ,w—rmm. v ”.2.” � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Mechoulam, Rafael Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-8-492 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence