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                  <text>V'—" —.

V

r‘w

.W—q“..- .

mp7. '..'~mvlw"-u'.

~wr-1-

um‘ wwm www.mm... m.—_____.,.__

v... v .__.__v

v

We _

.¢_~W--W..VMMVV,_

20 September 1971

Dr. Jon Heiser
University of California

Irvine, California

Dear Dr. Heiser,

that

I

Your experiences are most interesting, and
you are extending your studies.

am

delighted

In our assessment of the EEG changes with anticholinergic
drugs, the changes in the theta/delta (2-7 cps) and the fast
beta (22-30 cps) were the most interesting. We used a conventional
frequency analyzer in our studies, and confirmed some of the
changes with our computer analyses using period analyses. But
many years earlier, the same work had been done very well by
Romano and Engel in 1944 (AMM Arch Nburol Phyohiat.,51:356-377)
using hand methods. Should these prove too painful or expensive,
and a frequency analyser unavailable, we would be willing to
cooperate, should you be able to collect the tapes necessary
for our analyses.
most important measure would, indeed, be the EKG and
heart rate, and these could also be analyzed using some of the
available computer processing methods. But they can also be
done by hand and eye.
A

I

am

not clear about the 'csrdiovascular toxicity of the
have not been too impressed with the cardiovascular

tricyclics'. I

effects of our compounds except for thioridazine, which does have
clearly defined effects on cardiac function, and is interdicted
on that score in my units.
Hickey

is busy planning an extensive set of studies,

I am delighted to have him back. Give my best to
John Kramer (should he return from his infatuation

and
Elliott and
with the W.H.)

Bank

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

W”

_W. _r_.-wee_.

.v—w ..

m v»

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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