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                  <text>October 13, 1971
Dr. Monique Broude

NIMH

5600 Fishers Lane
Rockville , Maryland

Dear Monique,

I am writing to request five (5) additional grams
of diacetylmorphine (heroin) for our studies of the duration
of induced cross tolerance of 1-alpha-acetylmethadol and
methadone. These studies continue our evaluations of these drugs
under

FDArIND

6825 (methadone) and FDA-IND 6590 (1—a1pha-acetylmetha-

dol). In both these studies, heroin is used in the ”heroin
challenge” model (see reprint attached). we use single doses
of 25,50,and 75 mg heroin at 24,48,72, and 96 hours after a
dose of methadone or l—alpha—acetylmethadol to establish cross
tolerance.

These stddies are part of our NIMH study program, ”Opiate
Effects on Brain Function and Behavior", MB 19476, and a copy
of that protocal is enclosed.

I

also enclosing the appropriate BNDD drug request
I hold BNDD registrations AF1732103 and PF0024555
for research studies.
am

forms (2513).

le would be grateful for a renewal of our supply
of diacetylmorphine (heroin) for these studies.
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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