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                  <text>wx-

~n,
~

me

"4““:

October 14, 1971

#"W~,

W‘Ac:

‘71.:-

7-7.0

Dr.
FDA

Barrett Scoville,

M.D.

Rockville, Maryland
Dear

Barrett,
I

am

writing in reply to your request for information

from our study of l-alpha-acetylmethadol (IND 6590).

are completing the data analysis for the two
groups of patients, 10 each, who received methadone (100 mg daily)
or l-alpha~acety1methsdol (Bx/wk). Three of the patients are
now completing their 4th month of treatment, and our evaluation
period extends for 6 months in each case.
We

initial

it

is clear, however, that
l—alpha-acetylmethadol is equivalent in every way on a 3xlweek
schedule to methadone-w in patient acceptance, staff awareness,
urine test results, duration of antagonism (cross tolerance) to
injected heroin, and drop out rates. Indeed, I am impressed with
the data, and have asked my associates to complete a preliminary
report for your use, as I believe that further testing of this
drug is warranted, both in the maintenance of patients, and during
the ambulatory withdrawal schedules now actively used in my city.
From

the

I believe

Committee and/or
My

group,

you should

SAODAP

alert the

Methadone Advisory

that such data is available shortly.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

difference in our recent results from earlier published
results is in the dosage schedule of 70-70—80 mg.

P.S.

The

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