http://exhibits.library.stonybrook.edu/mfp/files/original/164759ca6b8eca05867cd74914217ff8.pdf 5b06e96640099e4a734c39a44df69b37 PDF Text Text mar—VW'WRIW“ July 2, Dr. Jerome 3-}. 1971 Jaffe Special Counsultent to the President The White House Hashington, B.C. Dear will Jerry, The grapevine has you be off for Viet~Nam, an& I trust your trip helpful in clarifying the facts of drug abuse along our servicemen and their dependents. called earlier this week, and I freely shared our data £150 sent him a copy of the program of the looting on narcotic antagonists to be held in Aberdeen, July 12-13, and a copy of a small project to get studies of M-soso off the ground. Roger with him. 1 It is apparent that neither NIHH, BEBE, ”AS/NRC, nor industry have provided the leadership to develop the antagonists. I believe the appointment of either I committee or an ”office* for this dovelopment would be a necessary first step. New York City mas established such a committee but included no one with dedication or interest and A. it is ineffectual. In answer to your questions, the projects that are important (1) Testing cyclazocine prophylaxis in Viet-Ncm, using available oral doses of 2~4 ng/day, coubined with.naloxonc during the (2) a rapid induction schedule, first Develop u long acting week. antagonist. (a) Contracts for trials with naloxone, using such methods as depotaoil, silastic, plastic film; this (b) Change import quotas fOr (c) Trials for thebeine and import other raw materials for naloxone; and, establish supply of naloxone for clinical research. and u long an adequate acting cyclazocine. �—~e:an‘-m-MWWW Jaffe Dr. -2- July 2, 1971 unn- " ‘vvf iv Test and establish the pharmacology, clinical toxicology (3) ~— clinical trials with and useful, introduce it M—SOSO and into trials of EN If either 1639A. compound a long acting formulation. is (4) Clinical trials of cyclarocine or naloxone in direct comparison with methadone or l—alpha~acetylmethadol. B. The "guesstimate" costs for the projects, on a "crash" basis: (I) frophyl§§i§_- for consulting expenses US-VietNam, 4—6 $10,000; local military costs; supplies to be defined staff by Sterling~Winthr0p based on size of study. members (2) — Long acting development (lst year). $800,000 (4 contracts Naloxone Thebaine and naloxone supplies $250,000 Cyclazocine status of (3) M—5050 Pharmacology 1639A, but for M-SOSO: and EN Animal pharmacology Clinical trials Supplies .m— : 6 VA (4) clinics, Clinical 600 added to present C. Role If 1639. I do ? not 9 $200,000) know the $42,000 120,000 50,000 Comparison Cyclazocine-Methadone: $200,000 organization cost patients, additional VA allocations of $400,000/unit. for myself. you establish a commission, I suggest you consider F. Blane or K. W. Bentley I would be pleased to be J. Villareal, D. Jasinski, G. (Great Britain), J. Woods and A. Kurland. A. Freedman, a member or to chair it. I have been actively soliciting the cooperation from industry a few years and now know many of the people who could be involved in a long acting drug research program. If a committee were set up and given the support its studies justified, the programs would be successful in a reasonable time. They may require some special regulations regarding financial rights to industry, however, and some cooperation from BNDD. for , �<_:-v..- "1"” . Dr. Jaffe -1- July 2, 1971 Should you wish to undertake this program yourself, or have Roger, John or someone else do it, I will make my files available and introduce your appointee to the appropriate persons. Incidentally, Villareal and Kosterlitz are chairing a symposium the antagonists in Aberdeen, July 12~13 and you may wish to attend or send someone. I sent Roger a copy of the program in case you had not seen it. on Again, my best wishes for the rapid success of your mission. Sincerely yours, Fink, M.D. Professor of Psychiatry Max � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Jaffe, Jerome H. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-6-407 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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