http://exhibits.library.stonybrook.edu/mfp/files/original/f1623e243b493b3d4de82b54858af4ab.pdf f91f34e2b87052d11ac64d3506f5428a PDF Text Text July 6, 1971 Dr. Jonathan U. Cole Boston State dospitel Boston, Massachusetts Dear Jon, Don Shapiro and I have reviewed the comments on our report, “EEG Profiles of Fenfluraninc, Amobarbital and Dextroamphetsmine in Normal Volunteers“ (Ar785), and thank you for them. The figures do represent our data as well as we have found, but the reviewer may be correct in asking that the ordinate be clarified. be better Would "Standard Score Based on Pre~Drug Mean and Sigma" than “Difference from Pre~Medicstion Mean”? If this is better, the printer can change these in the glossy prints in the will have the figures remcaptioned. original; or, we I believe Table 11 does show something better than the text, and I would like it published. "Your comments on page 5 are most helpful. We have rewritten the paragraph, and have inserted a corrected page 5. The second reviewer asked about order effects for fenflursmins when it was introduced st.the end of the series in some subjects. We examined our data for order e~fects and found none for drugs, but did for differences in the first records from subsequent records (pg. 7). The first session effect (similar to the first night effect in sleep EEG research) was accounted for, however, by the random drug assignment. of female subjects was a problem. we found that the women (due to the variability of prs~drug records was higher in and male this observation subjects, menstrual cycle?) then in our of child woman in plus our reluctance to use experimental drugs experiment. since this males only bearing age has led to our use of some BBC by sex except differencss We do not have any data on adequate and not is this suggestions that females are more variable, Our use for publication. �“v.1: m...“ v “we-" A— pnmw‘xw‘m—r. —.' 'n'l" WW w'l‘w—m 1 www— w "—I-v—wvm-w-w-r r... .__..,—yv -2- Dr. Cole Finally, the speculation and I thank you mechanism of July 6, 1971 action of fenfluramine is is of great interest. for your support of our programs. prompt consideration, and for your continued Please advise as to the figures. My best regards. Sincerely yours, Max Fink, M.D. Professor of Psychiatry Mszt enc . a matter of � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Cole, Jonathan O. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-6-404 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence