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                  <text>May

12, 1971

Dr. Daniel X. Freedman

Chief Editor

Department of Psychiatry,
University of Chicago
950 East 59th Street
Chicago, Illinois 60637

Box

2011

Dear Dan,

RE:

M83

0658 Revised

Thank you for your letter and critique of our ECT study
and Bilateral ECT: Effects on Depression, Memory

”Unilateral

We feund the suggestions cogent
and the Electroencephalogram“.
and we have nade the following changes and revisions.

1. In addition to the multivariate analysis, a description
of the pre« and post-ECT mean depression scores is included.
2.

The

classification of patients into endogenous or reactive
clarified, and reference to our unpublished manuscript

groups has been

deleted.
3.

a

The sources of bias of concern

to the reviewer

(non-random

assignment, non~blind assessment, concurrent drug therapy) are discussed

more

fully in the text,

4. We now clearly
each treatment .

and then noted in the Synapsis~Abstract.

state that each patient

5. The study of Strain gt_§g;,
importance.

is

now

had a grand mal

seizure

accorded a more proper

6. The sections on EEG and on memory are reduced to a few
sentences summarizing work reported elsewhere (Brit. J. Psychiat.,
Die. Harv. Syst. ) .
7.
We

and ask
My

The time

of post-treatment evaluation has been clarified.

would be honored to have
that you reconsider this

this report appear in the Archives
revision.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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