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                  <text>May

12, 1971

Dr. Frederic A. Gibbs

720 North Michigan Ave., Suite 620
Chicago, Illinois 60611

Dear Dr. Gibbs:
I am pleased to have you print my letter of February 26,
in Clinical EZectroencephaZOgraphy. Your journal can make a
significant contribution to the growth of EEG as a science by

critically

that

reviewing the

articles submitted

meet the high standards of a

and publishing those

quantitative science.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1971

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'

'

,

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WWE‘HVF-W'rwtmrmmm"‘4—,-sw“;.-vwmm'W‘W'WWWW

February 26, 1971
Dr. Frederick Gibbs
1427 N.

Chicago,

Astor St.

Illinois

60610

Dear Dr. Gibbs:
Your recent

editorial (Clinical

EEG,

l;

127)

asserts that

"cannabis indica produces no marked or consistent changes in the
EEG" and ”... the changes they [psychotomimetic drugs] produce in
the electrical activity of the cortex are of the same minor order
as are produced by tobacco”. It is difficult to see how you can
arrive at such sweeping conclusions, based on the data printed.
The report by Deliyannakis 33 a1., finds large effects of
cannabis, in a few subjects, with equipﬁent of limited frequency
response. They make no effort at quantification and we have no
idea about the sample size, stability over time, artefact control,
Despite the limitations of equipment and technique,
filtering, etc.
they report large changes, albeit not in every subject.

In numerous studies of the EEG effects of heroin, LSD, major
changes have been observed and related to drug dosage, pre-existing
EEG and clinical effects
(for examples, see Ann. Rev. Pharmacology,
9: 241-258, 1969; Neuropharmacolqu, 9: 539, 1970). Such studies
show that large EEG changes are,common, drug and dose related, and

interestingly related to the behavior of the subject.

Considering the major strides made in quantitative EEG, it does
neither the science of EEG nor clinical practice a service to make such
sweeping assertions as "Let's face it, disordered psychic function,
either spontaneous or drug induced, commonly does not correlate with
major abnormalities in the waking electroencephalogram“.

.

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