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                  <text>To:

I.

A.

H.

?ROM:

Freedman, H.D.

Fink,

DATEr

Mby

17, 1971

M.D.

Proposals for Developing a LonguActing Narcotic Antagonist

SUBJECT:

Establishment of a research center with its own staff.
Since the leadership is in the nepsrtment of Psychiatry, such a
center can be seen as part of a large program in drug dependence,
based at the new Mental Health Center. Since the Center has 3
floors of laboratories, and 250 patient beds (29 already dedicated
to addiction on the 6th floor), it is a logical center for such
1.

research.

will need funds to equip the laboratories, appoint
chemists, pharmacologiats and pharmaceutical specialists, particularly
The program

those interested in addictions.

For equipment (assuming space be made availabe at the
estimating 1/2 the 3 floors.
$850,000
For personnel

Scientists

(lst year)
$35,000
staff

6 9

@
Supporting
each
$50,000

Clerical

MEG.

and

210,000
300,000

“econ-

550,000

__

‘UWWWW‘Vq—‘W’w

,

Supplies

40,00n

Consultants

20,000

The annual budget in years 3~10 should average $750,000, to be
supplemented by special project grunts as may be needed.

�.

—m=

For Consulting contracts to develop a silaatic vehicle,
e.g., Food &amp; Drug Research, Inc.
$70,000
80,000

1970~71
1971—72

‘80,000

1972-73

$230,000

For consulting contract, to develop physiological slow
release method based on non~silastic model.
e.g., Alza Corp.
$300,000
300,000

1971—72

1972*73

$600,000
For consulting contract, based on oil depot preparation
e.g., Dr. Pilpel, Chelsea College, England’
1971«72
1972~73

3

50,000

m_50,000

$100,000
To

develop alternate antagonists
(a) M~5050_Rcckitt

&amp;

Colman

www.crw

wv/

w

l.

Aiimal Toxicology §_l§J000

2.

Intral

w,

“7—,

Dose

Toxicology in

man

$90,000
wmmrww,

39

(b)

trials

year $70,000—100,000

15319.29:
WEN

1.
2.

assay,
dose finding
Supplies of drug

3.

Human

P‘mww‘w’wrm—W"

.r.

Long term
1

.

.iwvwwww

16,000

Supplies of drug20,000
Personnel
__70,000

"v

A-w

$

Human

clinical

trial

$

50,000
50,000

70,000/yr.

�</text>
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