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                  <text>Hay

2’4

, 1971

Dr. Rafael Mechculam
School of Pharmacy

Hebrew University

P. O. Box 517

Jenxsslem, Israel
Dear Dr. Meduﬂam:

Itwas agreat pleasure forustohearcfymn‘vnﬁcwith
we are mtt grateful for your assistance in our

cannabis, and

analytic problems.

discussed I am enclosing a swam cf the clinical
the narcotic antagonists, and sore reports from which ym
can obtain the citations for the chenical reports. We believe that
a long acting antagmist is a logical and useful way to treat opiate
dependence and have sought to encourage the develoment of such a
fomzlatim. Should you or your associates be interested in this
problem, we mmld be pleased to go into the details and make
available the notes frcm our present contract with Food and Drug
eRseardi Inc.

data

As we

on

new theoretical interest is the data presented on EA 11476 ,
the l, 2 dinethyl heptyl melon of tetmhydmcarmabinol. Dr. Russo 1
Monroe shand me scare EEG records of the early studies in monkeys,
and these darmstrated a persistent, high voltage slow wave (3 5 cps)
pattern. This EEG pattern in awake subjects, is characteristic of
the post-convulsive therapy state and is associated with behavioral
inpmvement in depression. I am enclosing some early renorts, and
would encourage you (and/or SK?) to extend the trials‘of EA 11:76 in
um.
I an also mclcsing a copy of your report as you requested.
Of

Again, our thanks for your

disassicn.

Sincerely yours ,
Max

Fink,

M.D.

Professor of Psychiatry

HF :kt

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