http://exhibits.library.stonybrook.edu/mfp/files/original/c8b6af1be4337c24fa7f6332c79fc6cb.pdf d4adf20f4246ca411cf81a943fdb4ca7 PDF Text Text June 18, 1971 Dr. F. A. Clark, Jr. A. H. Robina Company 1&07 Cummings Drive Richmond, Virginia 23220 Dear Fred, It was kind of you to read our report on fenfluranine so carefully. EEG profiles of I agree that the choice of the word "tolerance" ig_unfortunate, after reading the final report I have accepted your suggestions. I am grateful to be able to correct my tent and replacement page: 13 are encloaed. These reflect a better discussion and should replace page 13 in the earlier draft. I will correct the text in galley. and Our clinical study of fenfluramine was unsatisfactory in that observed the subjects weekly and depended on verbal reports and recollections of interim events. Our subjects reported drowsiness the first few days, waining by the end of 7-10 days, and not recurring with gradual dosage increaaea. 0n cessation, l recollect 2 subjects complaining of irritability and insomnia. This was insufficient evidence and discontinued by us. We did start some patients on placebo and transfer to fenfluramine. In retrospect, we should have started some on fenfluranine and transferred to placebo. I did not comment in my report because I did not "understand" that the various symptona may form some kind of a syndrome. we I regret that Ricklee’ summary wee presented in a prejudicial way. While "Drug A ie no better than" is equivalent to ”Drug A was ae good ae" as a summary of data showing no differences, the connotations are indeed different and we should await the actual data. In his second hie patients had weight lose and were sedated. etudy, as you eunnarize If this combination were anticipated by some obese patiente, may be it, faeorahly received. it �{wwwwwlw Dr. F. A. Clark, It has been Jr. -2- June 18, 1971 impression that a wider trial of fenfluramine as indicated, particularly since the many difficulties with amphetamines. I would be pleased to read the NDA material. my an anorexigenic was Mhny report. thanks for your comments and help in improving our fenfluramine Sincerely yours, Mex Fink, M.D. Professor of Psychiatry MF:kt � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Clark, F.A. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-5-302 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence