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                  <text>..
—

W-‘rr—w

ww-ww—wnwn—w—rw—w—v—mrw

-

M'W'

www—

March 1, 1971

Jeffrey B. Donfeld
Staff Assistant to the President

Mr.

The White House

Washington, D.C.
Dear Mr. Donfeld:

It was kind of you to take the time to encourage our research
in the narcotic antagonists, and we are most grateful. Dr. Freedman
has sent you reprints of our recent reports.
There is a need for a more intense effort to deve10p a formulation
of an antagonist effective for prolonged periods, in the order of weeks
to months. With the support of the New York State Narcotic Addiction
Control Commission, we have let one contract for such a development with
Food and Drug Research Laboratories of MaSpeth, New York. We are aware
of parallel studies by Endo Laboratories of Long Island, and by Seymour
Yolles of the University of Delaware. Considering the magnitude of the
addiction problem, perhaps more efforts could be encouraged in the hope
of a more rapid solution to this technical problem.
In support of this effort, there are two steps which your office
could consider. In the fall of 1969, we requested contract support from
the NIMH for developing a silastic vehicle and were told that the available
free funds were committed and no centract funds were available. In part,
this was related to the interpretation that available funds were designated
for methadone delivery systems. Perhaps, in the next HEW appropriation
requests, the funds considered for addiction treatment and research could
be designated for "biological therapy of Opiate dependencd'or other broad
designation, thus allowing the apprOpriate NIMH committees to support those

requests which

may

be

available.

a more direct effort, perhaps your office would be able to review
the logic of the develoPment of a long-acting antagonist, and if you found
the logic as compelling as we find it, you could bring this to the attention
of the Secretary, HEW or the Director, NIMH.
As

Again,

my

thanks for your encouragement.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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