http://exhibits.library.stonybrook.edu/mfp/files/original/d2152bca12ef6fbf204700c8571cc6fb.pdf b542516f07a78223b25e8d3509ada10b PDF Text Text March 8. 1971 Dr. Edward L. Platcow, Ph.D. Department of Drugs American Medical Association 535 North Dearborn Illinois Chicago, Street 60610 Dear Dr. Platcow: As requested, I have read proposed chapter It is well written are few. and authoritative, 32 "Antidepressants". and my comments and suggestions Pg. 32$) Paragraph 1: Recent notes suggest that thiothixene (Havana) also has antidepressant qualities. We demonstrated such is my impression that Drs. Norman activity in our studies, and Pitts and Allen Borger at Pfizer Laboratories, Groton, Connecticut it can provide the available documentation. Paragraph 3. The role of ECT is presented in too limited a fashion. In every study of ECT and antidepressants, ECT is more effective and more rapidly (see Cole and Davis, in Freedman and Kaplan, "Comprehensive Textbook of Psychiatry“, 1967: 1263—1275; Klein and Davis. Diagnosis and Treatment of Psychiatric Disorders, 1969: 187~322). important, in suicidal risks, involutional melancholia, and psychotic agitated depressives, ECT may he 1ife«saving, while antidepressants are too slow and ineffective. Although drug evaluation is the focus, in my view, ECT is a complex way to achieve a biochemical change in the CNS ~ which is, after all, the goal of pharmacotherapy. Most Paragraph Too harsh an evaluation. The show many controlled studies. &. Klein and Davis Paragraph 5. depressions. A references cited by reason to emphasize the value of ECT in severe Pg. 259, Paragraph 1: English syntax is poor in phrase, ”..., since these agents block the actions of these antihypertensive agents". Paragraph 3. The duration of drug effects is generally 48~72 hours. The recommendation of a 2~week interval between tricyclic compounds and MAUI seems much too harsh, and too restrictive. Probably 72 hours are adequate. �y‘) Dr. Platcow March 8, 1971 —2~ Paragraph 9. I do not know the evidence for restricting imipramine in epileptice. My own data suggests it may reduce seizure activity in the brain, and may therefore be recommended. the data source be checked (see Canad. Peychiat. Assn. 166-171, 1959). A J., I suggest 6(Suppl.): restriction omitted is the use of imipremine in schizophrenia, where excitement states may be precipitated Plenum Press, 1965, 1; 53-61). (in Biological Psychiatry, Pg. 260, Paragraph 2. Same as ?age 259, Paragraph 9. Pg. 261, Paragraph 1. Sinequan is now prepared as a concentrate also. Pg. 262: Nialamide, and Phenelzine: Efficacy is suggested in endogenous depressions. The evidence is clearly that such patients show no response to HAOI, and if there is any application, it could be in the neurotic depressives. Tranylcypromine. Same as for phenelzine. Surely, there that tranylcypromine has been effective over ECT. I is would doubt that there are cases ”inapprOpriate for ECT” [such as?) who may respond to tranylcypromine. Pg. 263: no evidence I trust these comments are helpful. Sincerely yours, Fink, K.D. Professor of Psychiatry Wax MF:kt V .ww‘fiw ~v—w. :‘.’l.‘,‘ WWW” 93¢)Wmm- Wit-5. "at wa-MW � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Platcow, Edward L. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-3-232 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence