http://exhibits.library.stonybrook.edu/mfp/files/original/b9588a10ffc3b8161aa594629223e044.pdf 24b153d079bacf9a5b66dc81d22acbd5 PDF Text Text u, M" Wm Hatch 29, 1971 Dr. Fred Regan Manager, CNS Research Upjohn Company Kalamazoo, Michigan 49001 Dear Fred, Since our last note, we have established a dosage for diazepam, and begun our defined classification study of U 28,773. It should take 8 weeks for the data collection, and 2-3 for the analyses, so that I anticipate our report by mideune. L'flm. :. Your notes on the duration of action of U 23,773 are most with for clear so duration a interesting, effect, we may wish to approach the clinical effects in a study of a different design. A with a flat extended duration of action would be most powerful as an antianxiety agent. Our present problems with diaropam and chlordiazepoxide are their relative short duration of action, requiring repeated dosage, repeated risk of sedation, and the development of tolerance, requiring more frequent administrations in some patients. An effective, flat dosage regimen may avoid some of these difficulties. Your note, that a halfwlife > 24 hours would make you "bearish" is puzzling. Such a feature may increase the risks of uncontrolled use, but may be more useful in reducing the euphorigenic risks. The higher tithe, higher euphorigenic action, and higher addiction liability of heroin compared to methadone are documented. Both drugs effectively compound reduce opiate hunger, opiate withdrawal symptoms, and may usefully substitute, one for the other. Yet, methadone is considered the safer drug, with its longer duration of action. The extended duration of action enables some useful applications. Come visit New York soon. Meanwhile, even if the rubidium fever has cooled, the enclosed announcement may be of interest to someone on your staff. try to be there and will send you a summary if nouone else is able to go. I'll See you soon. Sincerely yours, Fink, M.D. Professor of Psychiatry Max MF:kt � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Kagan, Fred Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-3-177 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence