http://exhibits.library.stonybrook.edu/mfp/files/original/a667d162c7494245bbc35dbf0e4e3913.pdf 5afb5912265e1064363facca1b39e983 PDF Text Text Maw-n » I mr'r ‘ .«w . w." xmhwwwrhr'» ‘WWW'IMATWW.’ 1,“ ~rww"\-< www.msv- —...«—v... -.‘.-. m.“— w w.” .. nun-w, ,- w-pw—wm— my...” ~ .w... . .. .A February 9, 1971 < .17.. . \e s V,..,_flw..w... Dr. David Metcalf University of Colorado Medical Center 4200 East 9th Avenue Denver 20, Colorado .,v,-,W,w-,,. '5" Man-m yaw-re.“ <.... umiyv-mwtrn, Dear Dave, In 1965, NIMH supported a collaborative study of schizophrenic patients treated with placebo, high dose (1600 mg/day) and low dose (400 mg/day) chlorpromazine for 6 months. In one study, by H. C. B. Denber at Manhattan State Hospital, EEG records were collected pre-drug and monthly, from 2 lead pairs (RQ~RT ear, RF-RO). The records were accorded on magnetic tape and the tapes were analyzed in 1966 in St. Louis on the IBM 1710 data analysis system. Sample size was 30 seconds; 320 samples per second; without prefiltering; period analysis for baseline cross and first derivative. Of 120 .r‘vg’fiwmurww EEG patients, The sampling we had good records process was random, characteristics before treatment in 72 subjects. for there were no differences in the three treatment groups. among ,r—a'vmzr .m—r m1" wwrr‘ related changes for each variable using non— For both lead pairs, dose and drug related changes were found in an increase in theta activity and a decrease in frequencies above 40 cps. Variability of frequencies also decreased. We -. .v Ar wr-w-ezr-srv—r-r - F'rrm. :* v.1 emu-m vmv-nwu'l'fl .« w- «A «w vmwxwrwANW-u.‘ statistics. In an earlier study, Mme u examined the drug parametric we observed a similar in schizophrenic patients treated with 6 weeks (Fink, 1961). profile of EEG 1200 mg chlorpromazine change for These two studies indicate that changes in the EEG after chlorpromazine are drug specific, dose related in degree of change, and persist for periods up to 6 months of continuous treatments. �V“, _, ., Dr. D. Metcalf —2~ February 9, 1971 ,nywwm. It is clear similar studies, that the EEG changes with psychoactive drugs are not "side~effects" or “abnormalities" but direct effects of the drugs, reflecting the central processes which from these, and many they are supposed to effect. We failed to make direct correlations between the EEG change and behavioral improvement with the two doses of chlorpromazine in these patients, although there was a difference of drug gs; placebo. The differences between drugs were small,.and while significant in amount, the behavior changes were small. For a detailed discussion of the behavior changes, see Prien and Cole (Arch. gen. Psychiat., lg; 482-695, 1968). .r'v" xv uwxmm‘ifirww‘WW-swu ”nan-mgr” "neuter. If these comments are useful, they may be quoted either as "personal communication" or as presented at the Society for Biological Psychiatry, May 1967. Enclosed are abstracts and exhibits of the presentation. It was a pleasure to discuss these interesting problems. I met with Turan Itil in Aspen, and told him of your interest in the schizophrenia study in Copenhagen. He is the principal investigator and should write to you when he sets up the project. .1“, My , ”nan-r r7 best regards. Sincerely yours, yuan. rag-w” '3" .~ u Fink, M.D. Professor of Psychiatry Max y.v/;,1-Iv,'-‘.'_‘y.4u "Wt-w .m-u-g: ,mrgflswl. Janus-'1 MF:kt � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Metcalf, David Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-2-142 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence