http://exhibits.library.stonybrook.edu/mfp/files/original/807fda22455186407d74b1a130d059b3.pdf 47b9c98faa1ae7557310409cfdbefb56 PDF Text Text January 6, 1971 Dr. Arnold J. Singer, Chairman of the Board Reed and Carnrick Xenilworth, flew Ph.D. Jersey 07033 Dear Dr. Singer: recent meeting of investigators interested in cannabis, the proposed program next spring at the Academy of SciencesWewas have mentioned as a public presentation of the available data. the and believe two studies, recently completed the analyses of data to be relevant and possibly sufficiently novel to be of interest. At a have established the EEG profile of cannabis as inhaled by experienced users, in both acute single trials and in chronic (daily x 22 days) use. Subjects smoked cigarettes containing the equivalent of 7.5 mg or 22.5 mg THC. The data allows us to classify this compound we by in relation to the EEC profile classification previously published Of and special others. 1969) by us (Ann. Rev. Pharmacol., 2; 241-258. use ~ changes interest are the changes in EEG profile with chronic We would behavior. propose the which are associated with changes in and M.D. Volavka, H.D. Jan Max Fink, title "EEC Profile of Cannabis", by on immediate memory. and the and of marijuana. These data dose relation of the changes to task Jones and differ from those presented recently by Kiplinger, of Cannabis on ”Effects of We would propose the title Tinklenberg. M. Freedman, M.D. and Alfred Ph.D. Immediate Memory", by Rhea Dornbush, Our second study is of the effects There are two additional issues that are of interest to us that may be discussed at the conference. In oscwchronic trials, we have noted a decrease in "tolerance" to cannabis, the subjects developing dxpphoria after one week’s use. We are assessing the possibility that smaller doses may be needed after repeated exposure to achieve euphoria, and the recent reports of persistent tissue levels of cannabinols may be an interesting contribution. �.r— . v...“ - .- . ww4.v"v.« 2.- ('~‘-' (Aw—r m...» Dr. Singer . .n-g .7:¢'v.v-vv>. .- ,, ......, ~o~l+w .. . , ~2~ .N-.. in", ._ . «~ 4 new” .‘.. ,em .12.“. ., _ . . ”1,. January 4, 1971 have recently received a contract to study chronic cannabis users in the Near East, to assess the evidence for persistent sociological, social, and neurophysiological changes. In working through our tests we and sampling techniques, we became involved with the problems of establishing adequate controls for the chronic drug user. It may be useful to discuss these two the problem of "tolerance" on chronic use, and adequacy of issues, population samples for chronic trials, should the conference wish to review the immediate research issues. Our programs have been Institute of mental Health substantially supported by the National if our can contribute to the success of the proposed public presentations. my best wishes for the success of the conference. and we would be pleased Sincerely yours, ,. , Max 7””?va _. .: « ewe-nun Fink, M.D. Professor of Psychiatry MF:kt data , 5 � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Singer, Arnold J. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-1-080 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence