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                  <text>——....w~w.m.,.—v,.—

..,__....-

mrvm.._mm.w~._...u

January 14, 1971
Dr. Monique Brande

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

Dear Mbnique,

are continuing our studies of cannabis under HIMH~18172.
recent summary indicated that the absorption of active principle
via smoking is so rapid that many effects are maximal during the
20 minute smoking (2 cigarettes, 0.75 Gm, NINE marijuana). To
permit a shorter administration time (2 minutes) we have found it
useful to make up a small cigarette with sufficient extract (192 THC)
equivalent to 22.5 mg THC. This delivery system is effective and we
wish to undertake our next trials with this formulation.
We

Our

study, in male volunteers, 21 years of age or older (mean I 23)
is a single dose study, 7.5 mg or 22.5 mg THC equivalence. Subjects
are kept in the laboratory 4~6 hours. EEG and psychological tests are
Our

done.

have

ampules (SSC-61278 {RTI 1121~21A]) on hand. To complete
the pilot trials and a definitive study in 20 subjects at each dose will
require an additional 10 Grams of 17.1% THC, or the equivalent of 1500 mg
We

w

2

THC.

'

m-

I

rum—v

-':'.v

were.

do

appreciate your assistance.

Many

thanks.

Sincerely yours,

me

u—s—r-

-

rw-J'm"

Fink, M.D.
Professor of Psychiatry

Max

n-ww

w...-

yr.

wanna“

.m-wwwy

~

n—y-u—I—‘J

um:

,.

Iv“...

ampumwﬁ

ww-

"

Mrzkt

�</text>
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              <text>Correspondence to: Broude, Monique</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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