http://exhibits.library.stonybrook.edu/mfp/files/original/f9277c6ff06cc427f7062a336cd6f88e.pdf 42a24f89e995312d229bb4cf570f462a PDF Text Text January 14, 1971 ‘Dr. Jack Freund A. H. Robins Co. Richmond, Vtrginia Dear Jack, Enclosed is an answer from Paul Janssen to about sulpiride. It is of little help. Separately, I received Stille two my inquiry reports about clozepine from is a pharmacological review and indicates that clozapine has distinctive activity on a variety of tests, interpreted by Stille as characteristic for antipsychotic drugs. Angst gt 5;. is a clinical report in 126 patients with diagnoses of acute schizophrenia and mania. The essay is presented as a demonstration of the applicability of the collaborative, computerized data collection and analysis system, so that much of the text is devoted to technical features. But they are impressed that clozapine has distinct antipsychotic activity with two important features: no effect on muscle tone (i.e., no parkinsonism) and a marked improvement of sleep disturbances. The separation of antipsychotic and parkinson features is considered sufficiently novei as to become the basis of a test of the accepted theory that all antipsychotic drugs must produce parkinsonism. Clozapine is Dr. Hippius. and Hippius described as not having antidepressant or antimanic features. If these data are verified, the compound should be active. refer to a comparison with laevomepromazine and with thioridazine, claiming that clozapine is at least as effective an antipsychotic as these compounds; noting also that it has not been compared to the They piperazine phenothiazines. An additional report not available to no ArzneimitteZ-Fbrschung 19:496-498. 1969. It sounds like an interesting compound the reports of sulpride). My best. is Gross and Langner, (better perhaps than Sincerely yours, Max Fink, M.D. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Freund, Jack Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-025-1-052 Date A point or period of time associated with an event in the lifecycle of the resource 1971 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence