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                  <text>January 25, 1971
Dr. Larry Stein

Laboratories

Wyeth

P. 0. Box 8299

Philadelphia. Pennsylvania

lQlOl

Dear Larry.
I very much enjoyed your formulation of a theory of
schizophrenia. While fanciful. it has the merit of some
experimental study.

0n re-reading Ben‘s summary of imipramine in schizophrenia
(pp. 278-279). my comment still stands: there is no convincing
clinical evidence that imipramine has antipsychotic pronerties.
and Remmen gt glé_- a poor clinical
Hexquotes your theory (1962)
vo ume.

Enclosed are some reprints

report

on

that

may

interest you. Pollack's

disorganization of schizophrenia

by imipramine; Kramer's

statement on combined imipramine - chlororomazine; our study of
chlorpromaline;(0uprocyclidine) in depression; and a report by
Itil on high dose fluphenazine. The more recent data on higher
dose fluphenazine can be obtained directly from him.
My

regards.
Sincerely yours.
Fink. M.D.
Professor of Psychiatry

Max

MF:kt
ENC.

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