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                  <text>Four"): my w. mr nava—mv-w-w—wa“

'

--

Wm v”&lt;' w. mow-aurrwvwwvr me-jy .FuuﬂWLmI—w—u—rmu,

w-‘m

~~

vw m-V‘I.V'.
.

w

ku Jr Wmprrmrw'i",

7-.

V

w

.

_

October 9, 1970
Dr. Louis Harris
Department of Pharmacoloqy
University of North Carolina School

of Medicine

Chapel

Hill, North Carolina

Dear Lou.
As we

discussed,

we now

have a supply of

M-SOSO

and would

like to undertake single dose trials in man to assay the duration
and degree of antagon
3m to injected heroin.
If these are
successful, we would assay chronic oral dosages (2-4 weeks) and
assess the degree of antagonism; and then develop a parenteral
formulation, hopefully of long duration.

abide by prevailing practice, we will need animal toxicity
file for an IND. Our letter to the FDA is enclosed. I
would value your opinion as to what is needed. Can you
out
the project? At what estimated cost. for we would like carry
to present
such an estimate to the New York State Narcotic Addiction Control
To

data to

Commission.

I look forward
My

to seeing

you in Puerto'Rico.

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
enc. Letter to

FDA

Science summary.

�</text>
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