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                  <text>August 3, 1970
Dr. Noreen

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Norman,

have completed the next step in the EEG profile analysis
of CP 14,368. In a comparison of single 250 mg oral doses in
male volunteers, we did not elicit a systematic EEG pattern,
although the usual behavioral and BBQ effects of a placebo were
we

inhibited.

Failure to

or the dose of

elicit

CP

the profile may relate to the sauple site
to the possibility that at this dose,

14,368 - or

its central effects

are variable and unsystenatic.

.

mw”

-ww-wn

ww-ymw.r'.

I an not convinced that the sample site is too snail, since
elicited a well defined profile with the same subjects in
another compound, under the some conditions. If the problem is
the dose selected, then we should consider a repetition of the
study at a higher dose or a multiple dose study.

we

I would like the opportunity to meet with Al ﬁeissman and
other scientists at Pfizer with an interest in C? 14,368. This
will make it possible for no to check my experiences with theirs
and provide the basis for recommendation.
I will be away until September 1. but would like to arrange
1 meeting,
that is possible, early in September. Separately
I am sending you three copies of the data books and the summary

if

report.

Thank you for your cooperation ind
examine this interesting compound.

for the opportunity to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc: Dr. Berger

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