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                  <text>v.

.

mmsm.--mW—wwww...s-.ww.~...-.,.w

Septenber 3, 1970
Dr. Arnold

J.

Mandell

University of California,
P.

O. Box 109

San Diego

LaJolla, California 92037

owu—PWWrsw

.“ww...

Dear Arnold,
I look forward to seeing you in sunny California in February.
There are two topics under study here that would interest the Society.

l) Antggonists in Opiate Dependence: The conditioning model of
opiate depen ence suggests that ”do-conditioning“ could occur if self-

stimulations (needle + drug) went unrewarded repeatedly. Successful
treatment of opiate dependent subjects with narcotic antagonists
(cyclazocine and naloxone) provides support for this theory, and the
basis for a useful therapy in this and other addictions (as amphetamine
and alcohol) (presented with A. M. Freedman).
Convulsive Therapy:

2)

Recent modifications of convulsive therapy

(unilateral convulsions, multiple monitored seizures, inhalant induced
seizures) have focussed interest on the relation of memory change,

altered brain function (EEG) and behavioral change (improvement).
Unilateral induced seizures produce significantly less change in various
asymmetric EEG changes and equivalent behavioral changes
to bilateral induced seizures. This dissociation of therapeutic and
”side" effects allows multiple seizures to be given in one sitting -

memory

tests,

with therapeutic benefits. These observations are of interest to the
theory of convulsive therapy and to the relation of brain function and
tests of memory (both immediate short term and delayed).
I
My

trust that either topic will interest the

members.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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