http://exhibits.library.stonybrook.edu/mfp/files/original/97e719f49bea56f468a86c9d722e8039.pdf 2f2cad6a14472c573645f4abd26447b4 PDF Text Text w- I'd-“Yi'fl’v‘ CW? .... _ v.9 'Im'wu'v 'r|:\<':‘-V' «unww—MWY— «yum ‘7’ . _ Y, ._.,.., _~-. .. .IV-‘yfiv"-n new «Vaultsv‘ . .. September 10, 1970 v“ VIP-"Wm“ ....-.-..wr. Fm Dr. William Tabor Robins A. H. 1407 Cummings Richmond, Virginia 23225 n—rv y-u-uwv‘uw', mw-w Bill, Dear I have read the protocol of AHR 3000—E (butaperazine) dated 6/10/70 with interest, and believe we can participate in the assessment both of the bioavailability and therapeutic equivalence of BPz tablets and concentrate. I find one serious problem with the design. '"W'JWII. :- .wvwns-w—wwarw-m-v 'v" “wavy.- '1 ‘ $1:me for it, each subject is to receive tablets SP: transfer directly to concentrate BPz, at the dosage as tablets BPz. The assumption is that the equivalence As I WV'VX‘I'I'Ffi'AHWW'm 6 same understand weeks and then of the two formulations will be assessed by the continued improve~ nent of the patients. Such a conclusion is valid only if psychotic patients deprived of active antipsychotic medication would uniformly relapse on drug withdrawal. But such is not the case, and on cessation of antipsychotic medication a number of patients may maintain improvement for many weeks after withdaawal (see Gottschalk gt_gl;, Comp. Psychiat.. 11: 123-140 (spec. pg. 135]; Kamano, Psychol. Rep., 19: 743-749. 1966; Gittelman et a1., Psychopharmacology A Review of Progress. 1119-1154, 1969). Thasy“f? patients treated for 6 weeks are given placebo, not all will relapse within the next 6 weeks. this reason, that the patients randomly concentrate 8?: first; and for those who stabilize in 6 weeks, transfer to the other formulation for a second 6 weeks - avoiding the objection raised in my mind. For receive tablets ““mr.1i1-v My - BF: and I would suggest best regards. Sincerely yours, Fink, M.D. Professor of Psychiatry Max MF:kt up- u. “4.. ..w-- � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Tabor, William R. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-024-8-418 Date A point or period of time associated with an event in the lifecycle of the resource 1970 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence