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                  <text>a.
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July 3, 1970
Dr. Ed Domino

Lafayette Clinic

Detroit,

Michigan

Dear Ed,

It was kind of you to spend so much time with me on
Tuesday. I was very impressed with your facilities and with the
catalog of interesting studies which ydu and your associates are

undertaking.

I am particularly interested in your studies of
acetylcholine and cholinesterases. For the past 18 months, I have
studied the behavioral, EEG and memory changes induced by unilateral
and bilateral ECT, and recently have expanded the
study to include
multiple monitored ECT, in which the subject receives
3-8 seizures
1g one sitting. In reviewing our data, and in View of the
interest
in CNS neurohumors in depression, I became interested in measuring
the neurohumors in the spinal fluid of these subjects.
Alex Karczmar expressed enthusiasm for this study, and
have planned to send him samples, taken before and
after the
induced seizures. As you know, the techniques are
notoriously
difficult, and any collaboration and assistance, would
be most welcome.
If the problem is of interest to your associates, I would
to make samples of spinal fluid available to you as well. be pleased

we

If the problem is of interest, may I ask that you arrange
to have your assistant write, describing the necessary
to be taken in sample collection, sample size, shipping,precautions
etc.; and
we will send you a detailed protocol (now under
revision) and make the
necessary arrangements for the fall.

trip

my

thanks for your time, and my best regards in your
It sounds interesting and I look forward to a report

to Russia.

this fall.

BSncerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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