http://exhibits.library.stonybrook.edu/mfp/files/original/6d185d5ef2273f6742b20c4cb05a3678.pdf d5e755352f9a3e4dd1b5398177332236 PDF Text Text July 3, 1970 Dr. Allen Berger Pfizer & Co. Groton, Connecticut Dear Allen, first I enjoyed your visit installment of the material on June 23, and I we am discussed. enclosing the have prepared a protocol for the assay of the Infiuence of.PCPZ"5h Tolerance and Physical Dependence in Opiate Addicts. We have reviewed the administration schedule, and following your discussion, have added trials of PCPA on alternate days and daily, if the schedule of every 4 days is inadequate. 1. PCPA. We , for this project, that is one technical problem5-HIAA. we do not have and 5-HT urinary blood of the measurement of have contract these and to will the facilities for this measurement, can be done in unless they commercial laboratory, measurements with a assuming the contract the costs, Our for estimate your laboratories. is $3,000. number tested, of maximum cases project proceeds to the There have reviewed the data on cidoxepin and Presumed Anti-Anxiety, prepared a protocol, Elinioal Trial of CidaxapinWe would like to assess Dependence. Anti—Depressant Agent~ In Opiate 2. Cidoxepin. We in this the possibilities of clinical trials of anti~depressants of patients. number limited a in and a suggest trial special population, and clinical dosage define range a able be to In this study, we should definitive a be able to suggest will activity, and based on this data, trial. We the summer holidays, the supplies be able to begin the cidoxepin on or about September 15. will trials only after (we can begin the PCPA study in mid-July or as soon as are made available. 200 capsules of 25 mg. each should be adequate to 3. start; with EEG matching placebos if possible.) Trials in Prison Volunteers. This suggestion is most interestingT"EEa‘yafif'f5116fi=fip’feliphofi3'call to indicate that your technician will visit us on July 17 confirmed our enthusiasm. To will be necessary that equipment be available carry out this program , it ..,., , a A- . -‘Wrwv �at the prison to insure recordings that will be useful. I will describe our procedures and caution the technician, but the following should be considered: equivalent to Grass polygraph with 7P511 amplifiers. Grass Instrument makes a small 4 channel instrument, which can be initially equipped for recording on 2 chainels only. $4,500 ($3,000) EEG, Tape—recorder for FM. to the Hewlett Packard A 3690A. small 1/4 inch unit equivalent $4,285 Oscillator, equivalent to the 2020 HP $ 425 Oscilloscope, for monitoring, preferably dual beam, any make equivalent to the Tektronix 561 inexpensive. The tapes, paper, $1,000 and other supplies are relatively it would be useful for me and one member of my staff to visit the installation and develop the initial protocols in collaboration with your staff there. I would envisage the recording of EEG samples on paper and magnetic tape; having the paper records examined in conjunction with the clinical data; and then analyzing those tapes that seem the most useful for the definition of drug dosages using the advanced computer techniques of the EEG Prior to the studies, laboratory. not have a 1/4 inch FM tape unit in out computer center. It will be necessary for us to provide a duplicate unit or for you 00 lend us your unit whenever we undertake the analyses of the tapes. As I mentioned, we do 4. EEG Profile Study of Doxepin Pamoate. I have not received the pharmacological data for this formulation, and so have hesitated to prepare a protocol, but will do so as soon as the infor— mation is received. The thiothixene-EEG reports are progressing rapidly. Thank you these diverse studies. profile, and the for your suggestions, CP 14,368 EEG and I look forward to Sincerely yours, Fink, M.D. Professor of Psychiatry Max mf/ profile � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Borger, Allen P. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-024-7-381 Date A point or period of time associated with an event in the lifecycle of the resource 1970 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence