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                  <text>July 14, 1970
Dr. Thomas Williams

Clinical Research Branch,

Room 10Al9

National Institute of mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear Tom,

I visited Martin Kat: late last month, he told me that
Con~
you were returning to head the section on depression studies.
success!
wishes
for
and
best
your
my
gratulstions,
When

studies of ECT are progressing well. We have completed
the first study, s comparison of unilateral and bilateral HOT,
and found that unilateral electrode placement provides less
memory loss, less EEG abnormality (with non-dominant accentustion)
but, alas, less clinical ”improvement" as well. The data supports
Our

our

ECT

hypothesis of 1961 and 1966.

have begun MMECT, and in our pilot studies, confirmed the
only for unilateral electrode
feasibility of the techniques, not We
well.
are monitoring oxygenation with
placement, but bilateral as
EEG
during the seizure.
and
continuously
the
ear lobe oximetry
We have improved our techniques so that we are ready to undertake
a more definitive study in the fall.
We

,

._

..

“s
".1

.
,__._

.
:5,

"My“,

,4

-ms-Wu;.n.,-.,,

w-

“W‘FI-‘m-‘mem

discussed, there have continued to be some problems
in patient control at Gracie Square Hospital endows are now
negotiating for beds at Kirby Hospital (division of Manhattan
As we

State Hospital). This issue should be clarified by mid-September.
We have also begun some CSF collections and measurements,
collaborating with Alex Ksroznar of Loyola University, who is
willing to do the neurohumoral assays.
I am writing, however, not only to give you a progress report,
but to suggest that the time may be appropriate to call a meeting
of the scientists working in ROI and in memory, to review the
impact that unilateral electrode placement has on our understanding
of brain function, memory and behavior. My associates would
like to organize such a meeting, and would like your collaboration.
The meeting would
A tentative list of participants is attached.
and multiple ECT and memory mechanisms, with
from
chemistry and neurophysiology. The questions
contributions
of memory functions and the impact
localization
of concern: the

focus on

unilateral

of seizures, repeated or single; the possible alternate routes
of behavioral change with less memory impairment; and, the biochemistry
of seizures and their relation to memory mechanisms.

�‘-

era-czar?“

rr

Dr. Williams

-2-

July 14, 1970

Such a meeting could be held independently or in conjunction with
another society, as the Aspen Brain Research series (held in January).
We would be willing to contribute
substantially to financing the
meeting. It may be possible to generate an interesting volume on
ECT

in such a meeting.

martin suggested I send you these thoughts. As I will be away
would like to invite you to visit us in early September,
to discuss this meeting and to review our ECT program.

in August, I
Again,

my

congratulations on your

new

mission.

My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc: Dr. Katz
J. Shields
enc.

best regards.

�</text>
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