http://exhibits.library.stonybrook.edu/mfp/files/original/5e8063115e59c8a0cac81baba544e44e.pdf c093cd0ccac7cf38dfcd783c76952a55 PDF Text Text \\ 11‘ July 23, 1970 Mr. Robert Marlin Sandor Pharmaceuticals New Jersey 07936 Hanover, Dear Bob, Separately I am sending you a summary report and statistical data of our two EEG studies of 8 42,548 in volunteers. In the reported December 22, 1969, we defined a dose of first study, 8 4.0 mg of 42,548 as adequate to alter the behavior of our volunteer subjects. ' ' NMQ—‘l’fifflk ‘JW‘E‘M’E; w .- , , Nvi-mu we" mm?» In the second study, reported here, we compared the EEG profile of 8 42,548 to placebo. While many differences, particularly in behavior and systolic blood pressure were observed, we were unable to establish an EEG profile. As we discussed, the failure may relate to the sample size or dose of 3 42,548 ~ or to the possibility that its central effects are variable and unsystematic (at this dose). There are two options that are of interest to us and meet some of your needs. One is to extend this study by additional subjects at 4.0 mg or by an additional 6»12 subjects at 6.0 mg, in comparison to placebo, following this design. This will either demarcate an EEG profile, or failing to do so, satisfy the statisticians who may question our sample size. The second is to accept this data and proceed with a direct comparison with dextroamphetamine in a larger sample. This compound was the principal comparison in animal studies. If we define a profile for dextroamphetamine and not for 8 42,548, we can be confident that the CNS effects of 5 42,548 are less than amphetamine. Failure to define a profile for dextroamphetamine will raise doubts as to our technique. �-.- : 'wwvw'wv—w‘mmvm. z.,——_r.1x'_mu._—nw_,.\. V.‘,.,_.............n. we..-” ,_.. .w V .. ..v ”a", ,..-, we- . .._ we _ is w: 7 ‘— .— mew. Hr. Robert Marlin July 28, —2— 1970 rxu'vrv-Wii“ 1'Vrtrm“w"w~ (a Imitasmr TWVSI'W’V WWW,“ "'4 ym'r.‘ Before concluding the present study, however, you may wish to arrange a review of our data with other investigators of 8 42,548, both within and outside Sandoz Pharmaceuticals. I am leaving for my holidays in August, and would be pleased to participate in such a meeting in early September. statisticians to their analyses of the data, trusting that their results I would also be pleased to meet with your review are similar (but hoping they find more than we did). Incidentally, the study took much longer than I anticipated Now largely by our need to improve our statistics and programs. with that these are fully operational, I am sure we can proceed greater ease. My thanks for your cooperation in this study - and my best regards. Sincerely yours, Max Fink, H.D. Professor of Psychiatry Mszt � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Marlin, Robert L. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-024-7-311 Date A point or period of time associated with an event in the lifecycle of the resource 1970 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence