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                  <text>"wwvn‘

.uwun-grp".

June 2, 1970
Dr. Henry Adams

university of Georgia
Athens, Georgia
Dear

D .

Adams,

my associates and I have read your recent report, ”Electroconvulsive Shock, Brain Acetyloholinesteraee Activity and Memory" with
considerable interest. we would like to become acquainted with any
subaequent studies from your laboratory.

are aware, Ulett and his co-workers were unable to
even with higher dosages of'atropine (oft
Johnoon et al., Arch gen Psychiat., 2:324—336, 1960). In reviewing their
experiences, and our own with various anticholinergic drugs, we became
concerned that studies (particularly in man) that dependeddbn the
anticholinergic effects in the central nervous system were often
unsuccessful because the peripheral effects of'atropine exceed the
central effects, especially at low dosages. While the same is less
true for scopolamine, this compound also has extensive peripheral effects.
we tested a variety of active anticholinergic drugs and reported that
benactyzine, Ditran and diethazine seemed to elicit a higher degree of
central activity in proportion to their peripheral effects.(cj2 EEG clin.
As you

replicate their findings,

Neurophysiol. ,

12.- 359—369,

1960) .

time ago, I reviewed the available data on central
and
anticholinergic
cholinergic activity and the convulsive therapy
and
am
I taking the liberty of’enclosing a reprint that may
process,
Some

be

of interest.

Again, our congratulations on a nice piece cf’work.

Sincerely yours,

m Fink,

M. D.

Professor of’Psychiatry
mf/

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              <text>1970 </text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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