http://exhibits.library.stonybrook.edu/mfp/files/original/5abffa51fd9237f6b758ba90c2911382.pdf 31cfb2568fc10bb51ddc02d7be916f8c PDF Text Text war-Fr. April 9, w... ~.. 'R.'vm'r-rv Dr. Milton H. «”qu .u—s u ~ Chief, Joffe Drug Sciences ‘1‘ WWWvu-su—n-v mmwm-wmw. W" w—w—rz—r-«w-n—v-v 1970 Division United States Department of Justice Bureau of Narcotics and Dangerous Drugs Washington, D.C. 20537 w“. e Dear Dr. Jeffe: There are two programs relating to substance abuse in the Division of Biological Psychiatry of this Department. study program "Quantitative EEG Studies in Psychopharmacology”, partly supported by MH-lSSSB is dedicated to determining the relation of changes in brain fonction in psychiatric patients and volunteers in response to established and experimental psychoactive drugs. A summary of this work which has been continuous since 1954 was published in 1969 and reprints reflecting this experience are enclosed. The Our second program is dedicated to substance abuse, particularly opiates and alcohol. This program is largely supported by a contract with the New York State Narcotic Addiction Control Commission. The focus has been on determining the clinical efficacy of various psychoactive drugs in altering the drug dependent state. We have published our clinical results with methadone, cyclazocine, naloxone and tybanate. Because of our interest in neurophysiology, we have applied the techniques to our abuse studies and have reported the EEG changes with methadone, cyclasocine, and naloxone. Copies of these reports and some of the preprints are enclosed. same .wwwg...‘ W'-‘l -n— ;.-,m-rwmrv. \ ‘3 ; i F g k P , This program of research in substance abuse is new extended to alleged substances of abuse, notably marijuana, hashish and THC. While this work is unsupported, we are optimistic that the National Institute of Mental Health may look upon this work with favor. mwv u".- �Dr. Joffe April 9, ~2~ 1970 One of the special issues which has interested us has been the pharmacology of heroin and methadone. We have utilized intravenous heroin as a “challenge” to the cross tolerance of methadone and the antagonism of cyclazocine and naloxone. put this program in its proper perspective, you should that the principal investigator of some aspects of this nrogram is the Chairman of this Department, Alfred M. Freedman, H.D. Me is also co~director of the Center for Studies of Substance Abuse, another division of this Department, under the direction of know To Professor Richard Brotman, Ph.D. I trust this information is helpful. Sincerely yours. Max Fink, M.D. Professor of Psychiatry Mfi:kp � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Joffe, Milton H. Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-024-4-207 Date A point or period of time associated with an event in the lifecycle of the resource 1970 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence