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                  <text>April

10 , 1970

Dr. Jonathan 0. Cole

Boston State H05pital
Boston, Massachusetts 02129
Dear Jon,

After your telephone call, I asked Dr. Volnvka to check
on the question of hyperbnric oxygen and EEG, and the following
are his notes:

literature deals basically with two aspects of the
problem: oxygen convulsions and the therapeutic use of hyperbaric oxygen. The most recent work on convulsions (Morel,
Kerom and Levy, 1969), apart from asserting that the seizures
have a random origin (at least in the rabbit), also provides a
useful survey of the older literature.
The

Therapeutic hyperbaric oxygen effects on

were reported
by Levy-Alcover gt 31;, (1965), Marinchescu and Poilici (1966),
and Goulon et alt (1968). In patients with cerebrovascular
diseases, hyﬁergaric oxygen caused widely heterogeneous EEG
changes (either some flattening, or an amplitude increase, or
sharp elements) and this was interpreted as indicating that
oxygen might have resulted in cerebral vasoconstriction in some
cases. This would have accentuated any pro-existing hypoxia.
EEG

In London,iin 1966, a heterogeneous group of neurological
patients convalescing from brain anoxia or injury were introduced
in a hyperbaric chamber. I reviewed the records of 5 patients
and in this inadequate couple, saw changes reminiscent of the
initial stages of sleep ~ a lower of amplitude and slowing of
dominant frequency .

�Dr. Cole

The

April 10,

~2—

1970

references are:

Harel, D., Kerem, D. and Levy, S. The influence of
high oxygen pressure on the electrical activity of the brain.
Electroenceph. clin. Neurophysiol., 26: 310—317, 1969.
Dordain,

G.

Goulon, M., Levy-Alcover, M., Nouailhat, F. and
The BBC

clin. NeuroPhysiol.,

in hyperbaric oxygen therapy.
25: 90, 1968.

Electroencephl

Levy-Alcover, M., Goulon, M., Nouailhat, F. and Augustin, P.
of
study
patients undergoing hyperbaric oxygen therapy: first results.
Electroenceph. clin. Neurophysiol., 19: 608, 1965.
EEG

the

Marinchescu, C. and Poilici, I. ﬂyperoxic effects on
background activity in cerebrovascular diseases. Electroenceph.
Neurophysiol., 21: 95, 1966.

EEG

clin.

I

trust this is helpful.
Q

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp

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