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                  <text>-._

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Aprll 23, l97Q
Mr.

Charles

B. McCoy,

Presldenf

E. l. DuPont de Hemours, lnc.
DuPonf Bulldlng
Wilmlngfon, Dalaware l9898
Dear Mr. McCoy:

For more fhan lhree years, fha sfaff of fhls Department
of Psychlafry has collaborafed wlfh Endo Laboraforles ln fhe
cllnlcal fesflng of naloxone ln fhe freafmenf of oplale
dependence. Our flrsf cllnlcal frlals were reporfed In l968,
and slnce +hen we have encouraged Endo +0 make available
sufflclenf cllnlcal materlal +0 extend These frlals.

oral naloxane ls rapldly desfreyed, and fhaf
parenferal naloxone ls hlghly effecflva, we have repeatedly
recommended The davelopmen? of a longvacflng naloxona for fha
frealmenf of oplafa dependance.
Aware The?

Early In l969 we proposed such a development To varlous
agencles, lncludlng fhe Na+l0nal lnsfllufe of ManTal Health
and to The New York Slafe Narco+lc Addlcflon Cmnfrol Commlsslon.
We have recenfly been assurad a? flnanclal supper? from one of
fhase agencles, and may achlava addlflonal supporf from anofher.

for

Meanwhlle, we have requasfad Endo make supplles avallable
conllnued cllnlcal Trials, and once again, as ln l967-68,

hava recalved verbal assurances That fhe supplles will bﬁ
forfhcomlng, bu? fhey fall #0 malerlallze. A copy of our
communlcaflon ls enclosed.

lafasl

wlfh control assumed by DuPonf, and anflclpaflng The posslblllfy
of some changes in Endo's prlorlfles in fhe healfh care fleld,
l dlscussad our problems wlfh Dr.
Jurg Schnelder of your company
In February, and receivad a sympafheflc hearing.

"v“

'

�I

am

wrlflng

Today +0

brlng naloxone

To your

alfenflon.

Naloxone has some speclal publlc healfb posslbllllles. If
warrants a more rasponslva managerlal leadershlp ln maklng
oral supplles avallable for'audy, and ln exploring all feaslble
approaches To a long acllng parenferal form. May I ask your
alfenflon To fhls lmporfanf chemlcal and your encouragement ln
maklng fhe suppllas needed for conflnued cllnlcal sfudles?

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry
MP

:

kp

cc: Dr.

A. M. Freedman

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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