http://exhibits.library.stonybrook.edu/mfp/files/original/6550fdce97a8ade3ebcd495f8808529e.pdf a4ea667829e7f0efc9e0601f27cd2e14 PDF Text Text April 23, 1970 Dr. w. Clarke Wescoe President Winthrop Laborarorids 90 Park Avenue up — .gmq.<—,,.p.~,y.‘ New York, New York 10016 Dear Dr. fiancee: . .7, WW“ We have read of your appoinfmonf as President of winfhrop Laboraforids wifh inleresl, and 3rd wrifing To express our congrafulaflons, and To bring To your offdnilon, cyclnzoclne ~ a valuable producf devoiopod by Sioriing~Win+hroo and now in clinical trial. Since 1965, cyclazocine has been under sfudy in The iron?menf of Opioid dependence. fiuch of ind dafa of clinical pharmacology, parflcularly efficacy, seldcfed populafions, dosage, side effecfs and Their managemenf, have been collecfod in our lahorafories and have documonidd Those obsorvafions in numerous reporfs (see aTTached 115+). we The clinical applicability of cycldzocino has boon impressive, have been encouraged f0 underfakd more exronsive clinical Trials « a siudy in opioid depdndenf subjecTs-is in progross. and wo A principal problem in fhls froafmonl is The daily administraflon of dosage, for The oplafe dopendanl subJocf is noforiousiy unreliable. We have urged The developmdn? of a long-acfing, injecfable (or oral) form of cyclazocina. We are awaro of rho offorfs of Dr. Seymour Yolles of lhe Unlversify of Delawaro, under an NlMd granf. Such an effort alone seems inadequale lo The need, and we have suggesfed fhaf ofhdr roufos also be fried. w" ~ magnum Our suggeslions have boon made lo various local and halional health research funding sources and we have reconfiy been assured of financial supper? for such a study. weeks ago, called Dr. Joseph Bird of STeriing-Winfhrop, f0 sugges? a review of The clinical and technical sfudy programs Some '4‘«w"-mspnrvvrm-anwawmv «lav-1:1" 'r - WWW-V” awn-v» ,- eraRvL'H-‘uu we _<. my 1 of cyclazocine, requesfing fhe opporfunliy To presenf our recenf (unpublished) experiences, wilh The inienflon of sfimulafing renewed inferesf in This compound, and a more acfive coilaborafion in developing a long~acfing form of cyclazocine. �I am *0 your April 23, [970 ~2- Dr. Wescoe wrtflng affenflon, This program. To bring +he programs daveioped and To In your company of fhe presenf sfafus of urge your review Again, our congrafulaflons on your appolnfmenf, and our bes+ wishes for your conflnued success. Sincerely yours, Max Fink, M.D. Professor of Psychlafry MF:kp enc. A. M. Freedman Dr. Joseph 31rd cc: Dr. �April 2:, i970 PUBLICATION LIST Deparlmenf of Psychlafry York Medical College New Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Cyclazocine and Mefhadone in Narcofic Addicfion. JAMA, 202: i9l—l94, I967. Freedman, A. M., Fink, M., Sharoff, R. and Zaks, A. Clinical Sfudies of Cyciazocine in NarcoTic Addicfion. Amer. J. Psychia+., I24: l499-l504, I968. Freedman, A. M. and Fink, In The Treatmenf of 63: Fink, M. 59—69, and i968. iiil, T. M. Basic Conceprs and Use of Cyclazocine Narcofic Addicfion. Bril. J. Addlcf., EEG and Human Psychopharmacology iv: Clinical — A Review of Progress Anfidepressanfs. I957—i967, Efren, 0., Cole, J., Levine, J. and Wiffenborh, J. R. (E35.), U. S. Gov'? Prinfing Office, Washingion, D.C., pp. 497— In Psychopharmacoiogy 507, I969. Fink, and Human Psychopharmacoiogy. Ann. Rev. Pharmacoi., 9: 24i—258, I969. M. EEG Zaks, A., Bruner, A., Fink, M. and Freedman, A. infravenous Diaceryimorphine (Heroin) in Studies of Opiafe Dependence. Dis. Nerv. Sysf. Suppl., 30: 89-92, i969. Fink, Narcofic Anfagonis+s and Subsfilufes In Opiale Dependence. In The Presenf Sfafus of Psychofropic Druge, Cerlerfi, A. and Bove, F. J. (Eds.), Excerpfa Med. Fdn., Amsferdam, pp. 428-43l, M. I969. While, R. P., Drew, W. G. and Fink, M. of Agonisfic Actions of Cyclazocine I: 3l7-330, l969. Fink, Neuropharmacoiogicai Analysis In Rabbifs. Biol. Psychia+., and Freedman, A. M. Anfagonisfs in The Treafmenf of Oplafe Dependence. in Modern Trends in Drug Dependence and Alcoholism, Phillipson, R. V. (Ed.), Bufferworlh, London, M. pp. 49-59,-l969. Fink, M., Simeon, J., ilii, T. and Freedman, A. M. Clinical Anfidepressanf Acfivlfy of Cyclazocine - A Narcofic Anfagonisf. Clin. Pharmacol. Therap., ii: 4I-48, I970. Resnick, R., Fink, M. and Freedman, A. M. Cyclazocine Typology in Oplafe Dependence. Amer. J. Psychia+., I25: l256-2260, I970. �PUBLICATIONS (conflnued) PRESS 0mm IN Fink, M., Zaks, A., Resnlck, R., and Freedman, A. M. Treatmenf of Haroln Dependenca wlfh Opiate An*a§onlsfs. In purrenf Psychlafrtc Theraptes, Masserman, J. (Ed.), Grune and Sfra?+on, New York. FjékgwM;;*Zaks, A., Resnick, R. and Fraadman, A. M. Opiafa Anfagonlsfs In The Treafmen? of Heroin Dependence In Man. In Blochemlggi Phannacotogy of Narcofic Analgesic qugs, Clouef, D. ZEd.5, Plenum Publ. 00., N.Y. . V . "47157,le ,.;.~‘_...;,. .. .. 'I‘W"WI , a'Mn-Ii'vzr - QWWW‘ W a ’ Ww‘fim'fimwmn, QANV{.,.,&W.,V_,,X W ”.7“... y «um—3.31,?“ -,vxr- jump-v ~1n9n;..reyv.r~,w—~ my. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Wescoe, W. Clarke Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-024-4-174 Date A point or period of time associated with an event in the lifecycle of the resource 1970 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. 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