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                  <text>‘

March 4, 1970
Mr. Herb

Sturz

Institute

Vera

30 East 39th

New

York,

New

Street
York

Dear Mr. Sturz:

Enclosed is a draft proposal dated November 27, 1969, which
describes our suggestion to the National Institutes of Mental Health
and to the New York State Narcotic Addiction Control Commission for
the development of a long acting narcotic antagonist.
Since formulating the proposal we have had additional experience
with cyclazocine which makes us believe that the same principles and
techniques should be applied to the development of a long acting
form for cyclazocine as well.
For either naloxone or cyclazocine, the first step is the
development of a slow release form and a determination of a maximum
amount

that

can be concentrated in a

silastic vehicle.

The

initial

animal trials must be undertaken to determine the release rate.
These pharmacological aSSays can be done by a number of American
consulting firms. If this formulation is successful, then concurrent
animal and human trials must be undertaken in the animals for toxicity
purposes and in humans fer toxicity and the determination of the
duration of antagonism.

requested are for the pharmacological feasibility
such actions appear logical to you and your committee,
associates and I would be pleased to cooperate in any way possible.

only.
my

The fUnds

If

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszp
enc.

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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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