http://exhibits.library.stonybrook.edu/mfp/files/original/a98f99670a37db2765e3ae4f559dd7f6.pdf 46a3563a32773c87f7c34f1b4824f7b8 PDF Text Text March 14. 1970 Dr. Allen Hirsky Boston n.1versity $chool of Medicine Boston, Massachusetts Hoar Allcno, the publisher of the Clinical Eondbook of‘Pbychapharmuoology to write a testimonial, and I was about to do so without reading (the cxcollenco of the cast who sufficient), but was intercotefl in your chaptor. Alas. you must have doshod it of! in your early period, for surely tho viowa are not yours today. Or, are they 2 asked me The out of animal EEG data and single dosages leads to such atntcmcoto on " Fig. 3 and Fig. 4 illustrate tho relatively simplo affect [sic] that chlorpromnzino has on the EEG, as compared with the variety of effects seen over time with cccobarbital”. Chlorpromnzine is no more slmplo in its EEG affects and no dose 3 time sonaitivo as aecobarbital. ' 1.. "It is not the case, however, that there will always EEG effects of drugs." "."TYW‘IZ‘C' ‘4'.“ .1 "’wa'i‘i-E’“ '54. TILL 573917 277317.13 "9 be concordancc between the behavioral and Rotorooco to Wiklor emphasizes again tho fact that the Ems may not ha related to motor bohavior, especially in dumb beasts. The aissciiotion seen by Uikler and emphasized by Bradley is not the tuna in man, for heaviors that may be relevant to psychiatry, and this statement in a clinical volume presents the wrong vicw of human data. ’ ‘ “ fi‘Ji“ ~>Wm=w-;w~ "3‘93""1": The selection of Tables 1 and 2 increases this erroneous View. Bradley's ‘oxcited’.'drowsy' and ‘oormcl' reflect no behavioril moosurement or tank, but simple observation of motor behavior. Do you roally believe that 'excitod' after LSd and after atropine are the some [even 'f’marfi' .t‘té.‘ :;'~'t:'.'v_r» ' :-, :. ; .mvfil‘vflczfl’f‘ mammal: ;: 57'FTSITV5“;W€IE‘K: 3,12.“ .91» hold for Table sumo 2 in the unspecified species deccribed'by Bradley] is dose dependent, and thcso doses. but not for others. relationships may 1 �Mirsky O O I C O I O D O D I I O C O O I O O O O O O Page 2 There is more, but this should be enough to show where I disagree. I horn quoted your work in animals, as you know, as examples of what can be learned by careful EEG analyses plus caroful and relevant behavioral measurements. How can you quote Bradley's 1957 data in 1970. after your own work 1 Or, even after our review, that is, Bradley's and mine, of 1958 (Antioholinorgic Drugs and Brain Functions in Animals and Man, volume 28, Progress in Brain Roosarch,_£1oovier ) ? ; Perhaps, we should review the problem of EEG and behavior anew. Dissociation or Association are in the eye of the beholder, but presenting the viow of dissociation. based on animal data [without specifying spacioo l] in a volume devoted to man (CLINICAL HANDBOOK .'.] should be done cautiously and humbly, not carelessly, for the students for whom.the volume is intondod, will he unablo to assess the correctness or incorrectnoss of the text, and may be misled. my best regards. Sincerely yours, Fink, H.D. Professor of Psychiatry Max mf/ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. 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