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                  <text>February 28, 1970
Dr. William Drew

University cf Kentucky

Lexington, Kentucky
Dear Dr. Drew,
The

antidepressant paper is published in:

Pink, M., Simeon, J., Itil, T., and Freedman, A.N.: Clinical
Antidepressant Activity of Cyclanocinc~ A Narcotic Antagoniat.
Clin. Pharmacol. Therap.,_lg;élmé8, 1970.
Kaella and Karczmar citation is correct, ané the

articlc is chapter
The

52«71.

A, pp

preprint

activity of cyclazocine

on the

by

part of the article cited

EEG

identification of clinical antidepressant
criteria was not accepted anﬁ is

above (Clin. Pharmacol. Therap.)

Reprinta of chase articles arc not yet available,
but I will send them whcn they do come in.

It is good to have thc work on cyclazocine continued. It
an effective compound an&amp; I hopc that something therapeutic
can be made of it. Incidentally, we hcve bacn able t6 induct soma
patients on cyclazocine on a schedule of 1 mg, 2 mg, 3 mg and
4 mg in four days. For any side effects we have givaa either
parenteral or oral naloxone (2 mg IV or 50 mg oral) and the patients
can be discharged m uch sooner from the heapical than with methadone.
is

Sinceraly yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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