http://exhibits.library.stonybrook.edu/mfp/files/original/b29602d20d8dce8a2f133ed00e949ff2.pdf 707ce40ba83884b75f659c0821d5eeb9 PDF Text Text "I'M l . :‘rl‘auwlv"w'lwmrp‘.u~.x www- , January 1, 1970 Br. ?. J. Fell, N.V. Qrganon H.B. 035, Holland Doar Dr. Fell, It woo kind of you to write about our interest in computer analysis of tho EEG. Your miasion. as described in your is a commendable one, and I will do my host to assist you. mothods of letter, Thare is indeed much conflict about the value ofoortain ascoasmont. The history of the problem is very clear. EEG Since almost all practitionorl of EEG analysts dopond exclusively on visual analysis (done rapidly and profitably for clinical purposes), there are very few who have taken the timo to do quantitative assessmonta. Among the few who have used various quantitative methods, there in little disagreement; for ouch of on will anawcr the qunstion about relativo merits of each technique by asking, ”Merits for what purpose ?" Each of the quantitativo techniques have been useful in some project. This is true for analog power spectral density analysis or analog amplitude integration or analog period analysis: and similarly. digital computer methods for power, period and anplltudc; as well as digital mothoda for sleep prints, shape analysis, averaging, etc. In questiona. this framework, I will attempt to answer each of your l. The most sensitive oathod ? For what determination ? In are able to distinguish small doses of psychoactive drugs in volunteor human nubjocta using period unalyaio (320 samples/soc, 10 or 20 second epochs) or power soectrum (100 samples/second, 50 lags). We have separated 50 and 100 mg anobarbital; 50 mg fenflurnmiue from 50 amobarbital and 10 dextro-amphotamino; ate. our hands, wo digital computer programs era written for the IBM K), disks (2) and a fast printer. Those are available to qualified investigators approvoé by the fllflfi agonoios who oupportad our work; or at nominal coat to industry. However, I would suggest that it is not the packngos that you need (although those are helpful) as tho opportunity to work through town of the programs with members of our staff, particularly if your machine is diffetont. 1800 with 16K 2. Our (or 8 �_ ”m“ a, ._V r, .t dwl . uwxnmrmmn “i; d l \ PCJO Fall-OOOOIIOOIIOOOOJanuary1, 1970 It...OOUOIOOOCOOOOOOIOOUI0.0.0.02 The programs can run on the IBM 360/40 with 1827 converter. 3. The various technicalities I mention in my article small technical tricks that we have learned, painfully are the many and expensively, over 13 years of effort, to tease out drug effects from EEG records. The changes are there and when working with human subjects we are aware that it is necessary to control the environment for noise, alerting taska,, blood sugar, etc. These controls sound formidable on paper and are very simple in practice. A. The “W‘ same programs for sleep conditions as the other programs. prints are available on the recently been invited to consult with two other pharmaceutical firms, one in the U.S. and one in Europe, who have expressed similar interests to your own. We have found it helpful to visit us. suggest that a technical representative of your laboratory and attempt to we will make our facility available for your inspection make decisions the allow to you work through the questions that may you seek. In the event that it is useful, one of my co~workero or I could visit your laboratories, to describe the available processes, We have particularly in the context of your interests I trust those your inquiry, and my comments and needs. are responsive. Many best wishes for a successful 1970 thanks for ! Sincerely yours, Fink, M.D. Professor of Psychiatry Max mf/ � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Fell, P.J. 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