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                  <text>November 3, 1969

Dr. Ralph Jacobson
ENDO

1000

Laboratories
Stewart Avenue

Garden

City,

New

York 11530

Dear Ralph,

to confirm the telephone conversation of October 27.
You will be pleased to know that Dr. Zaks has been successful in
extending the duration of antagonism to heroin by naloxone. In
a subject receiving 3 Gus/day, 26 mg heroin, 25 hours after the
previous dose was experienced as a "blank", the subject exhibited
neither behavioral, physiological or EEG signs of heroin administration.
I wish

Dr. Zaks was planning

to retest the subject at

50 and

perhaps at 75 mg (at 24 hours). This experience is very
encouraging and I have asked Arthur to send you a detailed
summary and a plan for continued study as soon as he completed

the present series of experiments.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kp

�</text>
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              <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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