http://exhibits.library.stonybrook.edu/mfp/files/original/b03835e0ae755494c71f9093f61d8c39.pdf 3cdd5415a8ae05814e3a0c3c9b2e96fd PDF Text Text November 5, 1969 Dr. George Gardos Boston State hospital Boston, Massachusetts 02124 Dear Dr. Gerdos: I have read your preposal ”Perceptual-Cognitive Training High and Low Dose Thiothixene" with interest. It is an unbitious study and our laboratory is pleased to cooperate. The use of the Branch and Kornetsky of Chronic SchizOphrenics under data in conjunction with the EEG changes may give us some important information on the relation of EEG and behavior. The following comments are meant to elaborate the EEG details. range. This is too broad, and if possible should The EEG changes are different in young and old people. If ago is not controllable, perhaps years of prior drug use should be a factor in the assignment. 1. Age 2. Medication 3. During the placebo period, on be narrowed to 25-45. to assure intake.— may be given in liquid vehicle or concentrate BBQ discarded. The second should be done and placebo record will be the baseline record. Records should be attempted 4-7 days, 1,2 and 3 months. Leads: at time of CPT testing: left occipital vertex left frontal - occipital left ant.-temporal ~ vertex — bifrontal needle preferred Electrodes: Recording: 15 minutes eyes-closed. 180 seconds 5 hyperventilation minutes post hyperventilation �-2- Dr. Gardos 4. The use 1969 of amytal as a night-time sedative is a problem. If necessary, recordings should be delayed 48 hours after a Perhaps, chloral hydrate, paralydehyde, or methyprylon be as useful (and productive of less EEG beta activity). barbiturate. may 5, November 5. Analysis will be of 20 second epochs for pre~drug and 4 post-intervals. 2 leads, statistical analyses, will measure the low and high course of change, and adaptation (if any). The dose drug effect, It should be possible to rank the subjects for degree of change. The data may allow a measure of change in slow (1-7 cps), alpha, and fast (13—25 cps) frequencies to relate to the CPT and tests. other invited to visit Boston on January 15, 1970, that time. The details of tape recording, amplitudes, calibration signals, etc. can be discussed then, and I would like to see a calibration tape I have been and I can see the laboratory at tested. made and If funds it may be requested from NIHH or Roerig for this be advisable to include a budget for analyses, and I can discuss that with you in January. study, after We my The may can arrange visit to for Miss Logourtz Boston. abstract for the GIMP to work will be sent to Chairman of the Program Committee. in my laboratory Dr. Vinar, Sincerely yours, Max Fink, M.D. Professor of Psychiatry MF:kp P.S. associate, Dr. Shapiro, reminds me that a task to insure average level of alertness during the EEG recording is no "hgzzzziyghewgugggogmgnd the use of a simple auditory signal c scones This will not i ntlrfere with drug induced effects and drowsy. minimise the eve .0 effects of sleep. A simple device will be shes: wgring y u on your next visit. :iny . � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correspondence to: Gardos, George Type The nature or genre of the resource Text Identifier An unambiguous reference to the resource within a given context mfp-05-00-023-6-632 Date A point or period of time associated with an event in the lifecycle of the resource 1969 Creator An entity primarily responsible for making the resource <a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank">Fink, Max, 1923-</a> Subject The topic of the resource Correspondence -- Correspondence Relation A related resource The Max Fink Collection Description An account of the resource Rights Information about rights held in and over the resource <a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank">IN COPYRIGHT - EDUCATIONAL USE PERMITTED</a> Source A related resource from which the described resource is derived Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York). Language A language of the resource en-US Format The file format, physical medium, or dimensions of the resource application/pdf Publisher An entity responsible for making the resource available Contributor An entity responsible for making contributions to the resource Correspondence